Cryopreserved Fetal Liver Cells Immobilized in Macroporous Carriers Promote Liver Function Recovery After Injury With 2-Acetylaminefluorene

Authors

  • D. V. Gritsay Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • A. S. Lebedinskiy Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • O. V. Ochenashko Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • Yu. A. Petrenko Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Keywords:

2-acetylaminofluorene, partial hepatectomy, liver failure, cell therapy, cryopreserved fetal liver cells, macroporous scaffold, alginate

Abstract

The effect of cryopreserved fetal liver cells immobilized in macroporous alginate scaffolds on liver injury degree in rats with model of liver failure developed by administration of 2-acetylaminofluorene with subsequent partial hepatectomy. It was shown that immobilized fetal liver cells accelerated recovery of spesific hepatic indices: serum albumin, total bilirubin content, aminotransferase activity. The results of this work indicate the positive effect of fetal liver cells seeded in macroporous scaffolds on course of liver failure and argue the availability of this approach for liver failure treatment.

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Published

2024-05-21

How to Cite

Gritsay, D. V., Lebedinskiy, A. S., Ochenashko, O. V., & Petrenko, Y. A. (2024). Cryopreserved Fetal Liver Cells Immobilized in Macroporous Carriers Promote Liver Function Recovery After Injury With 2-Acetylaminefluorene. Problems of Cryobiology and Cryomedicine, 22(1), 88–96. Retrieved from http://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/101

Issue

Vol. 22 No. 1 (2012): Problems of Cryobiology

Section

Cryomedicine, Clinical and Experimental Transplantology

License

Copyright (c) 2020 D. V. Gritsay, A. S. Lebedinskiy, O. V. Ochenashko, Yu. A. Petrenko

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