Content of Nitric Oxide Final Product in Cartilage and Blood Serum of Rats at Low Temperature Modeling of Destructive and Dystrophic Process in Knee Joint

Authors

  • B. P. Vvedensky Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • L. N. Tynynyka Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • G. A. Kovalev Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • B. P. Sandomirsky Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Keywords:

nitric oxide, cooling agent, cryoinjury of knee joint, destructive-dystrophic process, cartilage tissue

Abstract

In the mechanism of cartilage tissue degradation the nitric oxide has been found to play an important role. There has been examined the content of NO (nitrite) final metabolic product in cartilage tissue of knee joint and blood serum of rats during low temperature modeling of destructive-dystrophic process (DDP) of knee joint, caused by cryoinjury. It has been shown that its content increases in aged animals, likely testifying to an accumulation of collagen glycolysated products, suppression by NO of matrix polyglycans, leading to impaired mechanical properties of cartilage tissue. At low temperature modeling of DDP the content of NO final product in cartilage tissue and blood serum in experimental animals was 4 times increased if compared with intact ones. The examined index did not virtually change for 7 days in cartilage tissue of rats, meanwhile under the analogous conditions it increased in blood serum, testifying to the development of DDP in cartilage tissue of animal knee joint.

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Published

2011-12-19

How to Cite

Vvedensky, B. P., Tynynyka, L. N., Kovalev, G. A., & Sandomirsky, B. P. (2011). Content of Nitric Oxide Final Product in Cartilage and Blood Serum of Rats at Low Temperature Modeling of Destructive and Dystrophic Process in Knee Joint. Problems of Cryobiology and Cryomedicine, 21(4), 421–429. Retrieved from http://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/114

Issue

Vol. 21 No. 4 (2011): Problems of Cryobiology

Section

Cryomedicine, Clinical and Experimental Transplantology

License

Copyright (c) 2020 B. P. Vvedensky, L. N. Tynynyka, G. A. Kovalev, B. P. Sandomirsky

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