Effect of Postural Changes, Postprandial Load, N. Vagus Pharmacological Denervation and Cryodenervation on Heart Rate Variability in Rats

Nikolai A. Chizh

Abstract


Heart rate variability (HRV) spectral analysis was applied to establish how postural change, accompanied by a change in the central venous pressure are associated with a very low-frequency (VLF)-component of the spectrum. Under postprandial load the total power of HRV spectrum was found out to decrease by 1.9 times due to reducing the very low-frequency component of the spectrum. A statistically significant decrease in the LF/HF ratio from 6.7 down to 4.8 due to an increase in the high-frequency range was noted. After treating the animals with Loperamide and Atropine sulfate, which inhibited a motor-evacuation function of gastrointestinal tract, there was established the effect of digestive system on HRV within the LF and HF ranges. The manifestation rate of HRV changes as a result of nervus vagus cryodenervation was shown to be significantly lower than after pharmacological denervation with Atropine sulfate. The ratio of LF/HF components decreased from 3.4 down to 1.3 due to the augmentation of high-frequency component of the spectrum. The findings demonstrated the parasympathetic nervous system to control all the ranges of spectrum and play a major role in HRV formation.

Probl Cryobiol Cryomed 2017; 27(3): 266-278


Keywords


heart rate variability; spectral analysis; central venous pressure; nervus vagus; cryodenervation

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References


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DOI: https://doi.org/10.15407%2Fcryo27.03.266

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