Study of Therapeutic Potential of Cryopreserved Newborn Rat Neural Cells in Rat Model of Intracerebral Hemorrhage

Kyrylo M. Zolotko, Oleksandr M. Sukach


Probl Cryobiol Cryomed 2018; 28(1): 054–058


intracerebral hemorrhage; rats; cryopreserved neural cells; transplantation

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Andres R.H., Guzman R., Ducray A.D. et al. Cell replacement therapy for intracerebral hemorrhage. Neurosurg Focus 2008; 24(3–4): E15. CrossRef

Atramentova L.O., Utevska O.M. Statistics for biologists: textbook. Kharkiv: NTMT; 2014.

Ben-Hur T., Idelson M., Khaner H. et al. Transplantation of human embryonic stem cell-derived neuronal progenitors improves behavioral deficit in Parkinsonian rats. Stem Cells 2004; 22(7): 1246–1255. CrossRef PubMed

Beray-Berthat V., Delifer C., Besson V.C. et al. Long-term histological and behavioural characterisation of a collagenaseinduced model of intracerebral haemorrhage in rats. J Neurosci Methods 2010; 191(2): 180–190. CrossRef PubMed

Cordeiro M.F., Horn A.P. Stem cell therapy in intracerebral hemorrhage rat model. World J Stem Cells 2015; 7(3): 618–629. CrossRef PubMed

Detante O., Jaillard A., Moisan A. et al. Biotherapies in stroke. Rev Neurol 2014; 170(12): 779–798. CrossRef PubMed

Fukunaga A., Uchida K., Hara K. et al. Differentiation and angiogenesis of central nervous system stem cells implanted with mesenchyme into ischemic rat brain. Cell Transplantat 1999; 8(4): 435–441. CrossRef PubMed

Hua Y., Schallert T., Keep R.F. et al. Behavioral tests after intracerebral hemorrhage in the rat. Stroke 2002; 33(10): 2478–2484. CrossRef PubMed

Jeong S.W., Chu K., Jung K.H. et al. Human neural stem cell transplantation promotes functional recovery in rats with experimental intracerebral hemorrhage. Stroke 2003; 34(9): 2258–2263. CrossRef PubMed

Lyashenko T.D., Sukach A.N. The effect of DMSO of different concentrations and freeze-thawing on newborn rat neural cell survival. Probl Cryobiol Cryomed 2011; 21(3): 263–273. Full Text

Montoya C.P., Campbell-Hope L.J., Pemberton K.D. et al. The "staircase test": a measure of independent forelimb reach and grasping abilities in rats. J Neurosci Methods 1991; 36(2–3): 219–228. CrossRef

Sang Y.H., Liang Y.X., Liu L.G. et al. A rat model of intracerebral hemorrhage permitting hematoma aspiration plus intralesional injection. Exp Anim 2013; 62(1): 63–69. CrossRef PubMed



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