Treatment of Orthopedic Implant Surface with Blood Serum-Based Composition Improves Their Biocompatibility

G. O. Lazarenko, O. M. Lazarenko, V. G. Guryanov, T. A. Alekseyeva, O. Yu. Furmanov


Probl Cryobiol Cryomed 2018; 28(1): 034–038


implant; rejection; biocompatible materials; adaptive composition

Full Text:



Aleksyeyeva T.A., Lazarenko O.N., inventors. Composition to improve biocompatibility of implants and cells for transplantation with a recipient's body and the way for its preparation. Patent of Ukraine №104738. 2014 Mar 11.

Aleksyeyeva T.A., Lazarenko O.N., inventors. Substance enhancing biocompatibility of implants with recipient body and method of its preparation patent application European Patent 2709684B1. 2016 May 25.

Dondossola E., Holzapfel B.M., Alexander S. et al. Examination of the foreign body response to biomaterials by nonlinear intravital microscopy. Nat Biomed Eng 2016; 1: 0007. CrossRef PubMed

Fabre H., Mercier D., Galtayries A., et al. Impact of hydrophilic and hydrophobic functionalization of flat TiO2/Ti surfaces on proteins adsorption. Appl Surf Sci 2018; 432: 15–21. CrossRef

Gallo J., Gibon E., Goodman S.B. Implants for joint replacement of the hip and knee. In: Materials for Bone Disorders 2017. p. 119–196. CrossRef

Huhn S., Braem A., Neirinck B. et al. Albumin coatings by alternating current electrophoretic deposition for improving corrosion resistance and bioactivity of titanium implants. AppliedSurfaceScience Mater Sci Eng C Mater Biol Appl 2017; 1 (73): 798–807. CrossRef PubMed

Lazarenko O.M., Smorzhevsky V.I., Galych S.P. et al. Clinical application of implant surface treatment with adaptive composition to improve their biocompatible features [method guidelines]. Kyiv; 2012.

Major M.R., Wong V.W., Nelson E.R. et al. The foreign body response: At the interface of surgery and bioengineering. Plast Reconstr Surg 2015; 135(5): 1489–1498. CrossRef PubMed

Pezzotti G., Yamamoto K. Artificial hip joints: The biomaterials challenge. J Mech Behav Biomed Mater 2014; 31: 3–20. CrossRef PubMed

Vadei L., Kieser D., Frampton C. et al. Survivorship of total hip joint replacements following isolated liner exchange for wear. J Arthroplasty 2017; 32(11): 3484–3487. CrossRef PubMed



  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


Institute for Problems of Cryobiology and Cryomedicine

23, Pereyaslavskaya str., Kharkov, Ukraine

Tel. +38057 373 4143; Fax +38057 373 5952