Influence of Some Î²-Blockers on Erythrocyte Hypotonic Hemolysis
Keywords:erythrocytes, hypotonic hemolysis, hemolytic pores, repair, antiglaucoma medicines
Influence of some Î²-blockers on human erythrocyte hypotonic hemolysis was investigated. Hemolysis extent and rate were shown to be inhibited as blockers concentrations increased in hypotonic medium within the concentration range studied. By contrast red blood cells pretreated with blockers became more sensitive to hypotonicity and less sensitive to blockers under the same conditions. The analysis shows that this effect cannot be explained by increased surface-volume ratio of cells, increased cation permeability of membranes or changes in membrane fluidity. It is assumed that blocking effect is attributed to stimulated repair of fluctuating membrane pores, which are formed at an earlier stage of hypotonic hemolysis.
How to Cite
Copyright (c) 2020 S. V. Rudenko, M. K. Said, Ye. L. Volovelskaya
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).