Influence of Some β-Blockers on Erythrocyte Hypotonic Hemolysis

Authors

  • S. V. Rudenko Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • M. K. Said V.N.Karazin Kharkov National University, Kharkov
  • Ye. L. Volovelskaya Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Keywords:

erythrocytes, hypotonic hemolysis, hemolytic pores, repair, antiglaucoma medicines

Abstract

Influence of some β-blockers on human erythrocyte hypotonic hemolysis was investigated. Hemolysis extent and rate were shown to be inhibited as blockers concentrations increased in hypotonic medium within the concentration range studied. By contrast red blood cells pretreated with blockers became more sensitive to hypotonicity and less sensitive to blockers under the same conditions. The analysis shows that this effect cannot be explained by increased surface-volume ratio of cells, increased cation permeability of membranes or changes in membrane fluidity. It is assumed that blocking effect is attributed to stimulated repair of fluctuating membrane pores, which are formed at an earlier stage of hypotonic hemolysis.

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Published

2010-04-19

How to Cite

Rudenko, S. V., Said, M. K., & Volovelskaya, Y. L. (2010). Influence of Some β-Blockers on Erythrocyte Hypotonic Hemolysis. Problems of Cryobiology and Cryomedicine, 20(1), 7–17. Retrieved from http://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/212

Issue

Vol. 20 No. 1 (2010): Problems of Cryobiology

Section

Theoretical and Experimental Cryobiology

License

Copyright (c) 2020 S. V. Rudenko, M. K. Said, Ye. L. Volovelskaya

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