Study of Low-Molecular Effect of Cryoprotectants on Mitochondria Respiratory Chain by Spin Probe EPR
Keywords:cryoprotectants, mitochondria, electron paramagnetic resonance, reduction of spin probe, inhibition of respiratory chain
Effect of low molecular cryoprotectants, glycerol, 1,2-propane diol and dimethylsulfoxide with concentrations up to 30% on activity of respiratory chain of rat liver mitochondria membranes has been studied by spin probe EPR. It has been established that lowmolecular cryoprotective substances induce inhibition of isolated organellesâ€™ respiratory chain. It has been shown that inhibition rate of spin probe reduction and mitochondria respiration as a part of hepatocytes is lower at the same concentrations, if compared with isolated mitochondria.
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