Effect of Cryopreserved Cord Blood on Activity of Alveolar Macrophages in Experimental Model of Influenza

Authors

  • Olga Yu. Kozhina Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • Maksim V. Ostankov Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • Lyudmila V. Ostankova Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • Nikolay A. Bondarovich Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • Anatoliy N. Goltsev Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Keywords:

alveolar macrophages, cryopreserved cord blood, influnza preventive maintenance

Abstract

Formation of resistance to influenza virus of type A in mice following introduction of cryopreserved human cord blood leucoconcentrate (cHCBL) or its components (plasma, nucleated cells). Bronchoalveolar lavage was obtained from mucous membrane of respiratory tract in experimental animals during influenza development. Analyzis of cell composition of bronchoalveolar lavage as well as functional activity of alveolar macrophages in lungs of animals in 7 and 14 days following influenza virus introduction. The infectioning was performed in 6 month after preventive intranasal introduction of cHCBL or its components. It was found that cHCBL in more extent than its components corrected the functional activity of alveolar macrophages increasing their phagocytic activity and preventing the immune deficiency development in animals with inducted viral pathology. Probl Cryobiol Cryomed 2013; 23(3):247–259.

Author Biographies

Olga Yu. Kozhina, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Department of Cryopathophysilogy and Immunology

Maksim V. Ostankov, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Department of Cryopathophysilogy and Immunology

Lyudmila V. Ostankova, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Department of Cryopathophysilogy and Immunology

Nikolay A. Bondarovich, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Department of Cryopathophysilogy and Immunology

Anatoliy N. Goltsev, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Department of Cryopathophysilogy and Immunology

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Published

2013-09-30

How to Cite

Kozhina, O. Y., Ostankov, M. V., Ostankova, L. V., Bondarovich, N. A., & Goltsev, A. N. (2013). Effect of Cryopreserved Cord Blood on Activity of Alveolar Macrophages in Experimental Model of Influenza. Problems of Cryobiology and Cryomedicine, 23(3), 247–259. Retrieved from http://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/301