Mechanisms of Glycerol Permeability through the Membrane of Human Erythrocytes
Keywords:erythrocytes, glycerol, permeability, activation energy, methods for assessment of permeability coefficients
The performed study provided the permeability coefficients of human erythrocyte membranes for glycerol in wide temperature interval (37...4Â°C) with step of 2â€“3 degrees. Using the Arrhenius dependencies the activation energies of glycerol molecules penetration into erythrocytes were calculated. The temperature range of 12...15Â°C was characterized with a break in Arrhenius dependence with a significant rise in activation energy in low temperature area. The obtained values of activation energy, 76 Â± 13 (37...15Â°C) and 159 Â± 15.6 kJÃ—molâ€“1 (12...4Â°C) testify to at least partial penetration of glycerol molecules through lipid bilayer. The paper discusses the literature data on coefficients of permeability for glycerol molecules, assessed with various methods.
How to Cite
Copyright (c) 2020 O. I. Gordiyenko, S. Ye. Kovalenko, I. F. Kovalenko
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).