Mechanisms of Glycerol Permeability through the Membrane of Human Erythrocytes
Keywords:erythrocytes, glycerol, permeability, activation energy, methods for assessment of permeability coefficients
The performed study provided the permeability coefficients of human erythrocyte membranes for glycerol in wide temperature interval (37...4°C) with step of 2–3 degrees. Using the Arrhenius dependencies the activation energies of glycerol molecules penetration into erythrocytes were calculated. The temperature range of 12...15°C was characterized with a break in Arrhenius dependence with a significant rise in activation energy in low temperature area. The obtained values of activation energy, 76 ± 13 (37...15°C) and 159 ± 15.6 kJ×mol–1 (12...4°C) testify to at least partial penetration of glycerol molecules through lipid bilayer. The paper discusses the literature data on coefficients of permeability for glycerol molecules, assessed with various methods.
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