Evaluation of Antitumor Effect of Combined Application of Cryoablation and Microwave Hyperthermia in the Experiment
Keywords:cryoablation, microwave hyperthermia, antitumor efficiency, experimental tumors
The study deals with assessment of combined application of cryoablation with following local microwave hyperthermia of sarcoma 37 inmice and Guerinâ€™s carcinoma in rats. It was found that one day post cryoablation of tumor there was a vascular stasis and pH shifted to the alkaline values, that provided favorable conditions for performing microwave hyperthermia. After using the combination of cryoablation and microwave hyperthermia the number of totally recovered animals was by 30% higher if compared with monotherapies, and life span of animals increased by 1.5â€“2 times, regardless of the primary tumor histogenesis. The results can serve as an experimental basis for combined application of cryosurgery with following microwave hyperthermia of the tumor in clinical practice.
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Copyright (c) 2020 V. H. Samadov, A. P. Kuzmenko, V. D. Zaharychev
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