Effect of DIDS Anion Transport Inhibitor on Erythrocyte Resistance to Change in Osmotic and Temperature Medium Parameters

Authors

  • S. V. Melikhova Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • E. E. Nipot Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • V. A. Bondarenko Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Keywords:

erythrocyte, posthypertonic lysis, electrolyte, non-electrolyte

Abstract

Erythrocyte sensitivity to posthypertonic lysis (PHL) was established to be dependent on dehydration medium composition, duration of hypertonic incubation and rehydration medium temperature. DIDS anion transport inhibitor causes a manifested protective effect on erythrocytes under PHL conditions when dehydration medium comprises a non-electrolyte. DIDS protective effect is slightly manifested and depends on rehydration medium temperature under dehydration in electrolyte solution. The factor, controlling erythrocyte sensitivity to PHL is assumed to be the rate of volume changes in erythrocytes at both incubation stages.

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Published

2006-09-15

How to Cite

Melikhova, S. V., Nipot, E. E., & Bondarenko, V. A. (2006). Effect of DIDS Anion Transport Inhibitor on Erythrocyte Resistance to Change in Osmotic and Temperature Medium Parameters. Problems of Cryobiology and Cryomedicine, 16(3), 254–261. Retrieved from http://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/581

Issue

Vol. 16 No. 3 (2006): Problems of Cryobiology

Section

Theoretical and Experimental Cryobiology

License

Copyright (c) 2020 S. V. Melikhova, E. E. Nipot, V. A. Bondarenko

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