Barbiturates and Lidocaine Effect on Erythrocyte Resistance to Hypertonic Hemolysis

Authors

  • N. V. Prokopenko Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • V. A. Bondarenko Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Keywords:

hypertonic hemolysis, erythrocytes, dehydration, barbital, phenobarbital, lidocaine

Abstract

Dynamics of erythrocyte hemolysis under transferring them into hypertonic solution (4.0 mol/l NaCl) with introduced barbital, phenobarbital and lidocaine at 37 and 0°C has been studied. Barbiturates and lidocaine were established to increase cell integrity under hypertony at 37 and 0°C. Protective effect is more manifested in phenobarbital. Under preliminary cell dehydration the erythrocyte integrity augments after dehydration in moderately hypertonic media. In that case barbiturates and lidocaine increase cell integrity as well.

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Published

2006-09-15

How to Cite

Prokopenko, N. V., & Bondarenko, V. A. (2006). Barbiturates and Lidocaine Effect on Erythrocyte Resistance to Hypertonic Hemolysis. Problems of Cryobiology and Cryomedicine, 16(3), 262–270. Retrieved from http://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/582

Issue

Vol. 16 No. 3 (2006): Problems of Cryobiology

Section

Theoretical and Experimental Cryobiology

License

Copyright (c) 2020 N. V. Prokopenko, V. A. Bondarenko

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