Proteinases and Its Inhibitor Activity at Artificial Hypometabolic State in Rats
Keywords:artificial hypometabolic state, proteinases, inhibitors of proteinases, brain, peripheric tissues
The proteinases, nontrypsin-like proteinases (NTLP), Î±-1-proteinase inhibitor ( Î±-1-IP) and Î±-2-macroglobulin (Î±-2-MG) activities in serum, tissues of cerebral cortex, brain stem, hypothalamus, cerebellum, lung, heart, liver and kidneys in rats under the artificial hypometabolic state (AHMS) attained by Andjus-Bakhmetiev-Giaja methods have been studied. Multidirectional changes of the indices of proteinase-inhibitor proteinase activity were revealed: total activity of proteinases slightly increased, the Î±-1-IP activity were stable to the influence, while the NTLP and Î±-2-MG activities demonstrated high sensitivity to the AHMS induced factors. Observing at AHMS the proteolysis activation mainly connected to increasing non-trypsin-like enzymes and Î±-2-MG level reducing in all examined tissues. In 24 hrs after AHMS the levels of the studied indices in general turned to initial levels with exception in organs which may have the maximum loading at AHMS development.
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Copyright (c) 2020 A. V. Shilo, V. V. Lomako, L. M. Samokhina, G. A. Babijchuk
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