Cold Stress as Corrector of Functional Architecture of Blood Brain Barrier in Aged Rats. Part 1. Fractal Analysis

Authors

  • V. G. Babiychuk Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • V. S. Marchenko Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • G. A. Babiychuk Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Keywords:

hypothermia, cryotherapy, ageing, blood brain barrier, ultrastructure, fractal morphometry

Abstract

Applying radioisotope methods, those of electron microscopy and fractal morphometry the functional architecture of blood brain barrier (BBB) of 24 month-old rats has been studied. It has been shown that pain and periodic cold effects of low positive and ultralow negative temperatures have structural and functional features of the response of BBB elements which are statistically and significantly found with the indices of fractal dimension (D). At pain and extreme cryoeffects the .D value of brain capillary endothelium monotonously increases up to ~1.5. At periodic effect of hypothermia .D is of manifested rhythmics (anti-persistent periods are found between persistent ones), testifying to a rise in plasticity, but preservation of structure resistance. When cooling the BBB permeability is increased for noradrenalin (if D~1.3) and acetyl choline (at D~1.7).

Published

2012-06-18

How to Cite

Babiychuk, V. G., Marchenko, V. S., & Babiychuk, G. A. (2012). Cold Stress as Corrector of Functional Architecture of Blood Brain Barrier in Aged Rats. Part 1. Fractal Analysis. Problems of Cryobiology and Cryomedicine, 22(2), 107-117. Retrieved from http://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/71

Issue

Section

Theoretical and Experimental Cryobiology