Molecular Peculiarities of Pro- and Eukaryotic Proteins Possessing Natural Adaptation to Low Temperatures


  • Aleksandr K. Gulevsky Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • Diana V. Tretiak Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov



cold adaptation, low temperatures, enzymes, structural proteins, amino acids, polarity, hydrophobicity


The review covers the findings in molecular modifications of proteins in cold-adapted organisms. According to the current data such modifications are attained via amino acid residue substitutions in a protein molecule, reduction of hydrogen bonds and salt bridges, hydrophobicity decrease. The specified modifications augment the flexibility of macromolecules thereby providing their functionality. The role of molecule-to-molecule interactions in protein stabilisation and their functional state within low temperature range is discussed.

Probl Cryobiol Cryomed 2015; 25(3):219-234

Author Biographies

Aleksandr K. Gulevsky, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Department of Biochemistry of Cold Adaptation

Diana V. Tretiak, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Department of Biochemistry of Cold Adaptation


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How to Cite

Gulevsky, A. K., & Tretiak, D. V. (2015). Molecular Peculiarities of Pro- and Eukaryotic Proteins Possessing Natural Adaptation to Low Temperatures. Problems of Cryobiology and Cryomedicine, 25(3), 219–234.