Effect of Cryopreserved Placental Mesenchymal Stromal Cells on Pro-Inflammatory State In Experimental Type 2 Diabetes mellitus


  • Yuriy A. Demin Kharkov Medical Academy of Post-Diploma Education, Kharkov
  • Mariya Yu. Demina Kharkov Medical Academy of Post-Diploma Education, Kharkov
  • Vladimir A. Shabliy Institute of Genetic and Regenerative Medicine of the National Academy of Medical Sciences of Ukraine, Kiev
  • Andrey N. Sergienko Medical Center ‘Professor Sergienko Opthamological Clinic’, Kiev




cryopreserved placental mesenchymal stromal cells, streptozotocin-induced diabetes, diabetic retinopathy, C-reactive protein, tumor necrosis factor a, pro-inflammatory cytokines


Diabetic retinopathy is the most common microvascular complications of Diabetes mellitus and one of the leading causes of a vision loss among people of working age. In this regard, the study of pathogenesis and development of new effective methods to prevent and treat diabetic retinopathy is one of the urgent tasks of current ophthalmology. Of particular interest is the use of mesenchymal stromal cells capable of penetrating into the injury site of blood vessels and tissue ischemia as well as having an anti-inflammatory effect. The paper assessed a therapeutic efficiency of cryopreserved placental mesenchymal stromal cells (cPMSCs) in experimental diabetes induced by streptozotocin and high-calorie diet. The results demonstrated that the cPMSCs preparation had an anti-inflammatory effect manifested in reducing the concentration of C-reactive protein and tumor necrosis factor-a in the blood serum, likely contributing to the prevention of diabetic microvascular complications.

Probl Cryobiol Cryomed 2015; 25(4):371-378.


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How to Cite

Demin, Y. A., Demina, M. Y., Shabliy, V. A., & Sergienko, A. N. (2015). Effect of Cryopreserved Placental Mesenchymal Stromal Cells on Pro-Inflammatory State In Experimental Type 2 Diabetes mellitus. Problems of Cryobiology and Cryomedicine, 25(4), 371–378. https://doi.org/10.15407/cryo25.04.371



Cryomedicine, Clinical and Experimental Transplantology