Mechanisms of Cryoprotectant Permeation via Erythrocytes Membranes

Authors

  • O. I. Gordienko Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv
  • E. A. Gordienko Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv
  • T. P. Linnik Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv
  • A. M. Kompaniets Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv

Abstract

The experimental data on permeability coefficients of human erythrocyte membranes for the series of cryoprotectants are presented. It is shown, that permeability coefficients are affected by both geometrical and physical and chemical parameters of molecules. The obtained results propose that when exceeding the molecules’ diameter over the value of 4D, the permeability coefficient reduces, perhaps, due to the decreasing of flow through the aqueous protein pores of a constant size. Permeability coefficients for comparatively hydrophobic molecules are almost directly proportional to the coefficients of partition between hydrophobic and hydrophilic phases, by pointing to a lipid way of permeation of these molecules through erythrocyte membranes.

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Published

2002-12-25

How to Cite

Gordienko, O. I., Gordienko, E. A., Linnik, T. P., & Kompaniets, A. M. (2002). Mechanisms of Cryoprotectant Permeation via Erythrocytes Membranes. Problems of Cryobiology and Cryomedicine, (4), 9–15. Retrieved from http://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/983

Issue

Section

Theoretical and Experimental Cryobiology