Effect of Rhythmic Cooling on Some Ethological and Biochemical Indices in Rats with Experimental Depression
Keywords:rhythmic cold effects, depression, behavior, proteinase, Î±-1-inhibitor of proteinases, Î±lpha-2-macroglobulin, rats
There were investigated the action of rhythmic cold effects (RCE) on behavioral structure and activity of proteinase inhibitor of proteinases system in rats with the model of endogenous depression (ED). Rhythmic cold effects on rats with ED contribute to the normalization of arterial pressure, partial restoration of behavioral structure and formation of searching activity elements that obviously occurs due to activation of non-specific protective organism reactions, restoration of disordered rhythm of CNS functional activity. During endogenous depression and RCE there is observed a significant activation of reactions of limited proteolysis and carrying-out of RCE in rats with ED contributes to the restoration of balance shift in proteinase proteinase-inhibitor system, probably transferring it to a new level of functioning.
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Copyright (c) 2020 V. V. Lomako, L. M. Samokhina
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