On the Modification of Immunoreactivity of Myelotransplant after Cryopreservation

Authors

  • A. N. Goltsev Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • I. Yu. Matsevitaya Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • Ye. D. Lutsenko Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • M. V. Ostankov Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • T. G. Dubrava Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • K. A. Goltsev Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • Ye. Ye. Yampolskaya Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Keywords:

bone marrow adhesive cells, cryopreservation, myelotransplant immunoreactivity

Abstract

The comparative analysis of structure-functional characteristics of bone marrow adhesive cells (BMACs) prior to and after cryopreservation was carried out. The data obtained confirm importance of BMACs as a component of myelotransplant with antigenpresenting function in the general mechanism of T-cell activation that induce graft-versus-host reaction (GVHR). The results allow to understand the mechanisms of immune interactions between cryopreserved allomyelotransplant and the recipient's organism and opportunities of applying the cryopreservation of bone marrow for minimization of GVHR.

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Published

2010-06-07

How to Cite

Goltsev, A. N., Matsevitaya, I. Y., Lutsenko, Y. D., Ostankov, M. V., Dubrava, T. G., Goltsev, K. A., & Yampolskaya, Y. Y. (2010). On the Modification of Immunoreactivity of Myelotransplant after Cryopreservation. Problems of Cryobiology and Cryomedicine, 20(2), 145–152. Retrieved from https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/203

Issue

Vol. 20 No. 2 (2010): Problems of Cryobiology

Section

Theoretical and Experimental Cryobiology

License

Copyright (c) 2020 A. N. Goltsev, I. Yu. Matsevitaya, Ye. D. Lutsenko, M. V. Ostankov, T. G. Dubrava, K. A. Goltsev, Ye. Ye. Yampolskaya

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