Ultrastructure of Thyrocytes in Young Rats at Neurogenic Arterial Hypertension and Following Administration of Cryopreserved Cord Blood Nucleated Cells
Keywords:arterial hypertension, thyroid gland, thyreocytes, ultrastructure, mitochondria, cord blood nucleated cells
In order to justify the expediency of application of cord blood preparations in therapy of neurogenic stress-induced arterial hypertension we carried out an electron-microscopic study of changes in ultrastructure of thyrocyte organelles in young rats with arterial hypertension prior to and after introduction of cryopreserved cord blood nucleated cells. The study of submicroscopic organization of thyrocytes demonstrated the presence of dystrophic changes in organelles, manifestation degree of which varied depending on the pathology development term. Submicroscopic architecture of thyrocytes in rats with stress-induced neurogenic arterial hypertension was established as acquired the normal structure one month later introduction of cryopreserved preparation of cord blood nucleated cells. Probl Cryobiol Cryomed 2013; 23(4):309â€“317.
Gluckman E.D. Cord blood as the source of hemopoietic stem cells for transplantation. Cell Transplantology and Tissue Engineering 2011; 6 (1): 12â€“14.
Yemelyanov D.N., Sharaevskaya Ðœ.V., Smirnova Ð¢.S., Degtyar Yu.V. Morphofunctional peculiarities of thyroid gland at chronic stress. Uspekhi Sovremennogo Estestvoznaniya 2008; (12): 44â€“45.
Lang G.F. Hypertonic disease. Leningrad: Medgiz, 1950.
Nasadyuk Ðš.Ðœ. State and perspective of cryostorage and clinical application of umbilical blood in Ukraine. Cell Transplantology and Tissue Engineering 2011; 6 (1): 98â€“104.
Petunina N.Ð. To the question on the state of cardiovascular system at disorder of thyroid gland. Mezhdunarodnyy Endokrinologicheskiy Zhurnal 2007; 4(10): 97â€“102.
Smolyaninov A.B. Cell and gene technologies in cardiology. â€“ St.-Peterburg, 2009.
Surkov K.G., Belova L.A., Krasnyakov V.K. Preclinical investigation of stem cell preparation â€˜Cryocellâ€™. Cell Transplantation and Tissue Engineering 2006; 1(3): 74â€“77.
Shosh I. Neurogenic hypertension. In: Disease Modeling / Ed. by S.V. Andreyev. â€“ Moscow: Meditsina. â€“ 1981. â€“ P. 246â€“247.
Patent N92227 Ukraine IPC Ð01N1/02. Method of cryopreservation of nucleated cells of cord blood including hemopoietic stem cells / L.O. Babiychuk, V.I. Grischenko, T.M. Gurina et al.; â„–200814009: Filed 05.12.2008: Publ.11.10.2010. â€“ Bul. Nr. 19.
Patent â„– 67199 Ukraine, IPC G09B 23/28. Method of modeling stress-induced arterial hypertension / L.V. Babiychuk, V.G. Babiychuk, O.V. Kozlov, V.V. Mamontov; Filed 29.06.2011, Publ. 10.02.2012. â€“ BuI. Nr. 3.
Harris D.T. Cord blood stem cells: a review of potential neurological applications. Stem Cell Rev 2008; 4 (4): 269â€“274.
Moise K.J. Jr. Umblical cord stem cells. Obstet Gynecol 2005; 106 (6): 1393â€“1407.
Newcomb J.D., Willing A.E., Sanberg P.R. Umblical cord blood cells. Methods Mol Biol 2009; 54 (9): 119â€“136.
Vanichsetakul P. Clinical use of cord blood for stem cell transplantation. J Med Assoc Thai 2005; 88 (2): 93â€“100.
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Copyright (c) 2020 Lyudmila V. Babiychuk, Vyacheslav P. Nevzorov, Olga F. Nevzorova, Vladislav G. Babiychuk
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