To Theory of Diagrams of State for Cryoprotective Solutions

Authors

  • Aleksandr I. Osetsky Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine

DOI:

https://doi.org/10.15407/cryo24.02.102

Keywords:

cryoprotective solution, cluster crystallization, diagram of state, vitrification, structure

Abstract

The paper considers the advantages of cluster crystallization model when describing phase transitions in cryoprotective solutions. The principles of plotting the diagrams of state are described, with emphasis on the fields of existing cluster phase. Basing on these diagrams the experimentally observed heat and volume effects are analyzed, which accompany the crystallization and melting of cryoprotective solutions. Herewith a special attention is paid to the distinguishing of phase curves, corresponding to cooling and following heating of the solutions and the definition of superposed diagrams of state was made to describe the processes caused by appearing differences. Model of cluster crystallization was used to determine the balanced structure state of frozen cryoprotective solutions and possible processes directed to their achieving.


Probl Cryobiol Cryomed 2014; 24(2):102-117.

Author Biography

Aleksandr I. Osetsky, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine

Department of Low Temperature Preservation

References

Bevan O.J., Goates R.J. Lamb J.D. Solid-liquid phase equilibria in water + ethylene glycol. J Chem Thermodynamics 1972; 4(1): 123–126. CrossRef

Bohon R.G., Conway W.T. DTA studies of the glycerol-water system. Thermochim Acta 1972; 4(3–5): 321–341. CrossRef

Boutron P., Kaufmann A. Metastable states in the system water–ethanol. Existence of a second hydrate, curious properties. J Chem Phys 1978; 68(11): 5032–5041. CrossRef

Boutron P., Kaufmann A. Stability of the amorphous state in the system water-1,2-propanediol. Cryobiology 1979; 16(6): 557–568.

Bronsteyn V.L., Steponkus P.L. Nucleation and growth of ice crystals in concentrated solutions of ethylene glycol. Cryo-biology 1995; 32(1): 1–22. CrossRef

Cocks F.H., Brower W.E. Phase diagram relationships in cryobiology. Cryobiology 1974; 1(4): 340–358. CrossRef

Fuller B.I., Lane N.A., Benson E.E. Life in the frozen state. Boca Raton: CRC Press, 2004. CrossRef

Khan R.W., editor. Physical metallurgy. Amsterdam; 1965.

Malsam J., Aksan A. Hydrogen bonding and kinetics/thermodynamics transition of aqueous trehаlose solutions at cryogenic temperature. J Phys Chem B 2009; 113(19): 6792–6799. CrossRef PubMed

Osetsky A.I. Peculiarities of state diagrams of aqueous solutions of cryoprotective agents. Cryobiology 2009; 59(2): 141–149. CrossRef PubMed

Osetsky A.I. Thermodynamic aspects of cluster crystallization in cryoprotective solution. CryoLetters 2011; 32(3): 216–224.

Rasmussen D.H., Luyet B.J. Complementary study of some non-equlibrium phase transition in frozen solutions of glycerol, ethylene glycol, glycose and sucrose. Biodynamica 1969; 10(220): 319–331.

Rasmussen D.H., MacKenzie A.P. Phase diagram for the system water-dimethylsulfoxide. Nature 1968; 220(174): 1315–1317. CrossRef PubMed

Zinchenko A.V., Zinchenko V.D. On phase transitions in the water-ethylene glycol system at zubzero temperatures under nonisothermal conditions. CryoLetters 2001; 22(3): 191–198.

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Published

2014-06-20

How to Cite

Osetsky, A. I. (2014). To Theory of Diagrams of State for Cryoprotective Solutions. Problems of Cryobiology and Cryomedicine, 24(2), 102–117. https://doi.org/10.15407/cryo24.02.102

Issue

Vol. 24 No. 2 (2014): Problems of Cryobiology and Cryomedicine

Section

Theoretical and Experimental Cryobiology

License

Copyright (c) 2020 Aleksandr I. Osetsky

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