Nitric Oxide Derivatives at Artificial Hypometabolism in Rats and Hamsters
Keywords:nitric oxide, hypometabolism, low temperature, hypoxia, hypercapnia
The response of NO generated system of hibernator (hamster) and non-hibernator (rat) to the combination of factors (hypoxia, hypercapnia, low temperature and darkness) that promotes the development of natural hypometabolism has been studied. The combined action of increasing hypoxia and hypercapnia at the background of cooling is thought to affect the same L-arginine-NO-ways, but it does not lead to serious disturbance of NO metabolism in hibernators and non-hibernators. All discovered changes were likely adaptive and in general have been restored in 2 h and leveled in 24 h after animals arousal from the artificial hypometabolic state. The only exception is the depressed level of NOx content in hamster blood.
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Copyright (c) 2020 A. V. Shilo, V. V. Lomako, T. N. Bondar, G. A. Babijchuk
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