Peculiarities of Hypertonic Cryohemolysis and Posthypertonic Lysis of Human Erythrocytes under Phenobarbital and Barbital Effect
Keywords:erythrocyte, barbital, phenobarbital, hemolysis, posthypertonic lysis, hypertonic cryohemolysis, dehydration
Dynamics of hypertonic cryohemolysis and posthypertonic lysis of human erythrocytes was calorimetrically studied along with the introduction of barbital and phenobarbital in different concentrations into incubation medium. Barbital and phenobarbital were shown not to change the level of posthypertonic lysis when erythrocytes hemolysis occurred as a result of hemolytic pore formation in the rehydration phase. During hypertonic cryohemolysis the osmotic and temperature factors are combined; erythrocytes damage is influenced not only by dehydration, but also by ionic transport. Barbital and phenobarbital decrease the level of hypertonic cryohemolysis along with the decrease of ions transport through erythrocytes membrane.
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Copyright (c) 2020 V. A. Bondarenko, N. V. Prokopenko
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