Effect of Medium pH and Ion Composition on Ratâ€™s Isolated Hepatocyte Resistance to Hyperosmotic Stress
Keywords:Hepatocyte, pH, osmolarity
The influence of the media with different cation and anion composition on ratâ€™s isolated hepatocyte resistance to the hyperosmotic stress effect under different pH medium was studied. It was demonstrated that a damaging effect increased in K+ - Na+ - Li+ cation series; CH3COO- â€“ Cl- â€“ NO3- anion series. A pH decrease results in the augmentation of cell resistance in all observed media, a pH increase, in contrast, reduces the cell resistance to hyperosmotic stress. A temperature decrease levels the effects of both ion medium composition and alkaline pH.
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Copyright (c) 2020 T. P. Sereda, S. N. Lezhanin, V. A. Koptelov, V. A. Bondarenko
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