Cold Stress as Corrector of Functional Architecture of Blood Brain Barrier in Aged Rats. Part 1. Fractal Analysis

Authors

  • V. G. Babiychuk Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • V. S. Marchenko Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • G. A. Babiychuk Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Keywords:

hypothermia, cryotherapy, ageing, blood brain barrier, ultrastructure, fractal morphometry

Abstract

Applying radioisotope methods, those of electron microscopy and fractal morphometry the functional architecture of blood brain barrier (BBB) of 24 month-old rats has been studied. It has been shown that pain and periodic cold effects of low positive and ultralow negative temperatures have structural and functional features of the response of BBB elements which are statistically and significantly found with the indices of fractal dimension (D). At pain and extreme cryoeffects the .D value of brain capillary endothelium monotonously increases up to ~1.5. At periodic effect of hypothermia .D is of manifested rhythmics (anti-persistent periods are found between persistent ones), testifying to a rise in plasticity, but preservation of structure resistance. When cooling the BBB permeability is increased for noradrenalin (if D~1.3) and acetyl choline (at D~1.7).

Downloads

Published

2012-06-18

How to Cite

Babiychuk, V. G., Marchenko, V. S., & Babiychuk, G. A. (2012). Cold Stress as Corrector of Functional Architecture of Blood Brain Barrier in Aged Rats. Part 1. Fractal Analysis. Problems of Cryobiology and Cryomedicine, 22(2), 107–117. Retrieved from https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/71

Issue

Vol. 22 No. 2 (2012): Problems of Cryobiology

Section

Theoretical and Experimental Cryobiology

License

Copyright (c) 2020 V. G. Babiychuk, V. S. Marchenko, G. A. Babiychuk

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

  • Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  • Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  • Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).