Study of Apoptotic Processes in Cells of Monocyte-Phagocyte System During Development of Adjuvant Arthritis Prior to and After Administration of Fetal Liver Cells
Keywords:apoptosis, monocyte-phagocyte system, adjuvant arthritis, fetal liver cells, cryopreservation
Rheumatoid arthritis (RA) is one of the most widespread chronic inflammatory diseases of the joints with multifactor etiology. A crucial point in RA is the disorder of proliferation and apoptosis in immunocompetent cells as well as in the cells of monocyte-phagocyte system (MPS). Using the model of adjuvant arthritis (AA) in animals we comparatively assessed the development of apoptotic processes in MPS cells before and after administration of native and cryopreserved fetal liver cells (cFLCs). By means of Western blot analysis we showed the peculiarities of CD-95 cascade proteins expression in MPS cells during development of AA. After administration of cFLCs we found more pronounced proapoptotic effect, which degree depended on the period of their
Probl Cryobiol Cryomed 2014; 24(3):249-261.
Bendele A.M. Animal models of rheumatoid arthritis. J Musculoskel Neuron Interact 2001; 1(4): 377â€“385.
Chereshnev V.A., Rodionov S.Yu., Cherkasov V.A. et al. Alpha-fetoprotein. Ekaterinburg: Uro RAN; 2004.
Dubich E., Semenkova L., Dubich I. et al. Fetoprotein causes apoptosis in tumor cells via a pathway independent of CD 95, TNFR1 and TNFR2 through activation of caspase-3-like proteases. Eur J Biochem 1999; 266(3): 750â€“761. CrossRef
Estaquier J., Ameisen J.C. A role for T-helper type 1 and type 2 cytokines in the regulation of human monocyte apoptosis. Blood 1997; 90(4): 1618â€“1625.
Fil'chenkov A.A. Caspases: regulators of apoptosis and other cell functions. Biochemistry 2003; 68(4): 453â€“466.
Goltsev A.M., Babenko N.M., Ostankova L.V. Use of embryo-fetoplacental complex products as correctors of autoimmune diseases in experimental model of allergic encephalomyelitis. Transplantologiya 2003; 4(1): 207â€“209.
Goltsev A.N., Dubrava T.G., Gayevskaya Yu.A. et al. Cryobiological technologies as a component of optimized methods in therapy of autoimmune diseases. Klin Imunol Alergol Infektol 2009; 1â€“2: 46â€“51.
Goltsev A.N., Dubrava T.G., Ostankova L.V. et al. Peculiarities of cryopreservation effect on functional potential of fetal liver hemopoietic stem cells of various gestation terms. Problems of Cryobiology 2009; 19(2): 186â€“199.
Goltsev A.N., Grischenko V.I., Rassokha I.V., Ostankov M.V. Possibility of using the embryo fetoplacental complex products to correct apoptotic processes under autoimmune disease. Problems of Cryobiology 2003; 4: 41â€“48.
Goltsev A.N., Grischenko V.I., Sirous M.A. et al. Cryopreservation: an optimizing factor for therapeutic potential of fetoplacental complex products. Biopreservation and Biobanking 2009; 7(1): 29â€“38. CrossRef PubMed
Goltsev A.N., Lutsenko E.D., Dimitrov A.Yu. et al. Peculiarities of functional state modulation of genetic apparatus of fetal liver cells with stemness characteristics after cryopreservation. CryoLetters 2011; 32(6): 543â€“544.
Goltsev A.N., Yampolskaya E.E. Cell apoptosis of monocyte-phagocyte system and mechanisms for its regulation. Problems of Cryobiology 2006; 16(4): 408â€“419.
Kinne R.W., Stuhlmller B., Palombo-Inne E. et al. The role of macrophages in the pathogenesis of rheumatoid arthritis. In: rheumatoid arthritis: the new frontiers in pathogenesis and treatment. Oxford University Press; 2000: p. 69â€“87.
Kovalenko V.M. Rheumatic diseases: modern trends in pharmacotherapy. Ukr Revmatol Zhurn 2009; 3 (37): 511.
Linehan S.A. The mannose receptor is expressed by subsets of APC in non-lymphoid organs. BMC Immunol 2005; 6: 1471â€“1477.
Mangan D.F., Robertson B., Wahl S.M. IL-4 enhances programmed cell death (apoptosis) in stimulated human monocytes. J Immunol 1992; 148(6): 1812â€“1816.
Pope R.M. Apoptosis as a therapeutic tool in rheumatoid arthritis. Nature Reviews Immunology 2002; 2(7): 1â€“9.
Sukhikh G.T., Bogdanova I.M., Malaytsev V.V., Fisenko A.P. Prospectives of using human fetal stem/progenitor cells in cell therapy. Bulletin of Experimental Biology and Medicine 1998; 126: 178â€“181.
Venkatarman M. Effect of cryopreservation on immune responses. VIII. Enhanced secretion of interferon-gamma by frozen human peripheral blood mononuclear cells. Cryobiology 1995; 32: 528â€“534.
Yampolskaya K.Ye., Goltsev A.N., Gurina T.M. Change in functional potential of fetal liver cells dependent from cryopreservation regimen. Svit Mediciny i Biologii 2007. 1: 89â€“93.
Zhang X., Goncalves R., Mosser D.M. The Isolation and Characterization of Murine Macrophages. Curr Protoc Immunol; 2008; Chapter: Unitâ€“14.1.
How to Cite
Copyright (c) 2020 Anatoliy N. Goltsev, Ekaterina E. Yampolskaya, Maksim V. Ostankov, Nikolay A. Bondarovich
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).