TY - JOUR AU - Gulevsky, Aleksandr K. AU - Akhatova, Yuliya S. AU - Shchenyavsky, Ivan I. PY - 2017/06/25 Y2 - 2024/03/28 TI - Features of Apoptosis, Induced by Temperature Reduction JF - Problems of Cryobiology and Cryomedicine JA - Probl Cryobiol Cryomed VL - 27 IS - 2 SE - Review articles DO - 10.15407/cryo27.02.097 UR - https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/1290 SP - 97-109 AB - <p><span id="tinymce" class="mceContentBody " dir="ltr">We summarised and analysed here the findings on apoptosis contribution into the cell damages, caused by temperature<span style="font-family: Arial; font-size: 8pt; color: #231f20; font-style: normal; font-variant: normal;"> deviation from the physiological norm (below 37°C). The participation of the caspases, causing the disintegration of anti-apoptotic Bcl-<span style="font-family: Arial; font-size: 8pt; color: #231f20; font-style: normal; font-variant: normal;">2 family proteins and proteolysis of the DNAase inhibitor, responsible for DNA fragmentation in the apoptosis, induced by a moderate<span style="font-family: Arial; font-size: 8pt; color: #231f20; font-style: normal; font-variant: normal;"> cell cooling, was shown. An important role in cold adaptation mechanism belongs to the RNA-binding protein (cold-inducible RNAbinding protein, CIRP), which is capable to prevent the oxidative stress-induced apoptosis development. We reported here the data,<span style="font-family: Arial; font-size: 8pt; color: #231f20; font-style: normal; font-variant: normal;"> confirming the participation of reactive oxygen species and antioxidant cell components: superoxide dismutase and human peroxiredoxin 1 in apoptosis and cold adaptation.</span></span></span></span></span></p><p><span class="mceContentBody " dir="ltr"><span class="mceContentBody " dir="ltr"><em>Probl Cryobiol Cryomed 2017; 27(2): 97–109</em><br style="font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;" /></span></span></p> ER -