Temperature Effect on Human Erythrocyte Membrane Permeability for 1,2-Propane Diol and Dimethylsulfoxide
Keywords:erythrocytes, permeability, 1, 2-propane diol, dimethylsulfoxide, Arrhenius dependencies
The paper presents the results of study of human erythrocyte membrane permeability for 1,2-propane diol (1,2-PD) and dimethylsulfoxide (DMSO) within temperature limits of 3-37C. Arrhenius dependencies of permeability coefficients for the studied substances were shown to be underwent the series of breaks within the following temperature limits: 8-12, 18-20 and 28-30C (being known as the critical ones for some functional indices of biological membranes) with sharp changes in activation energy (EA). Some possible mechanisms of thermoinduced changes in parameters of non-electrolytes permeation via erythrocyte membrane are discussed.
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