Peculiarities of Isolation, Cryopreservation and Allogeneic Transplantation of Rabbit’s Hepatocytes

Authors

  • A. S. Lebedinsky
  • A. Yu. Petrenko

Keywords:

transplantation of cryopreserved hepatocytes, alanine aminotransferase, aspartate aminotransferase

Abstract

The effect of introduction rate of hepatocyte suspension into a portal vein on transaminase activity in blood and liver morphology was studied. The obtained results have demonstrated, that the rate decrease of hepatocyte introduction when transplanting into a portal vein results in an even distribution of donor’s hepatocytes to recipient’s liver, allowing to reduce the thrombogenesis in the portal blood flow system and to decrease the damage degree for recipient’s own liver. The results can be used for studying the effect of transplanted cryopreserved hepatocytes at experimental pathologies of rabbit’s liver.

Author Biographies

A. S. Lebedinsky

Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv

A. Yu. Petrenko

Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv

Published

2003-05-15

How to Cite

Lebedinsky, A. S., & Petrenko, A. Y. (2003). Peculiarities of Isolation, Cryopreservation and Allogeneic Transplantation of Rabbit’s Hepatocytes. Problems of Cryobiology and Cryomedicine, (1), 51-58. Retrieved from http://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/1010

Issue

Section

Cryopreservation of Biological Resources