Effect of Amphiphilic Compounds on the Susceptibility of Partially Dehydrated Erythrocytes to Hypertonic Stress

N. V. Orlova, N. M. Shpakova


We have studied the effect of various amphiphilic compounds on the susceptibility of partially dehydrated erythrocytes to a hypertonic stress (4.0M NaCl, 37oC). There has been found a high antihaemolytic activity of the representatives of cationic, anionic, nonionic, zwitterionic amphiphilic compounds when removing the cells out of 0.45 and 0.7 M NaCl into the medium, containing 4.0 M NaCl. The values of antihaemolytic activity depended both on the peculiarities of the compounds studied, and on the initial state of cells, subjected to a stress effect.


erythrocytes; amphiphilic compounds; hypertonic stress; antihaemolytic activity

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