Problems and Perspectives of Using Stem Cells of Cartilage Tissues

Authors

  • Yuri B. Chaikovsky Bogomolets National Medical University, Kyiv
  • Serhii B. Herashchenko Ivano-Frankivsk National Medical University, Ivano-Frankivsk
  • Olena I. Deltsova Ivano-Frankivsk National Medical University, Ivano-Frankivsk

DOI:

https://doi.org/10.15407/cryo29.04.303

Keywords:

cartilage tissues, stem cells, experimental models, laboratory animals, cryopreservation of stem cells

Abstract

The paper aims at providing general information regarding the use of stem cells (SCs) for the treatment of cartilage tissue diseases for specialists in the field of biology, cryomedicine and biomechanics. To date, SCs niches have been identified in hyaline cartilage, synovial membranes and synovial fluid of diarthrosis, intervertebral discs, and knee joints menisci, fibrous cartilages of the temporomandibular joint and elastic cartilages of the auricle. Specific features and the mechanism of action of SCs of cartilage tissue were determined. Experimental models of cartilage tissue pathology in different animal species have been developed. Experimental studies have demonstrated the possibility of using SCs for the treatment of diseases caused by cartilage pathology. It is shown that the use of cryopreserved cartilage tissue SCs in medical practice is effective and promising. To date, this issue remains understudied, therefore, it is necessary to develop optimal freezing regimens, select cryoprotective media, as well as evaluate the safety of such a therapy.

 

Probl Cryobiol Cryomed 2019; 29(4): 303-316

Author Biographies

Yuri B. Chaikovsky, Bogomolets National Medical University, Kyiv

Department of Histology and Embryology

Serhii B. Herashchenko, Ivano-Frankivsk National Medical University, Ivano-Frankivsk

Department of Histology, Cytology and Embryology

Olena I. Deltsova, Ivano-Frankivsk National Medical University, Ivano-Frankivsk

Department of Histology, Cytology and Embryology

References

Aryaei A, Vapniarsky N, Ma DV, et al. Recent tissue engineering advances for the treatment of temporomandibular joint disorders. Curr Osteoporosis Rep. 2016; 14: 269-79. CrossRef

Bailey J, Fields A Liebenberg E, et al. Comparison of vertebral and intervertebral disc lesions in aging humans and rhesus monkeys. Osteoarthritis Cartilage 2014; 22: 980-5. CrossRef

Bright P, Hambly K. A systematic review of reporting of rehabilitation in articular-cartilage-repair studies of third-generation autologous chondrocyte implantation in the knee. J Sport Rehabil. 2014; 23: 182-91. CrossRef

Chan W, Tiffany Y, Au K, et al. Coming together is a beginning: the making of an intervertebral disc birth defects. Research (Part C). 2014; 102: 83-100. CrossRef

Chen S, Deng X, Ma K, et al. icariin improves the viability and function of cryopreserved human nucleus pulposus-derived mesenchymal stem cells. Oxid Med Cell Longev. 2018; 18: 1-12. CrossRef

Chisnoiu AM, Picos AM, Popa S, et al. Factors involved in the etiology of temporomandibular disorders - a literature review. Clujul Med. 2015; 88: 473-8. CrossRef

Cui G, Wang Y, Li C, et al. Efficacy of mesenchymal stem cells in treating patients with osteoarthritis of the knee: a meta analysis. Exp Ther Med. 2016; 12: 3390-400. CrossRef

Daly C, Ghosh P, Jenkin G, et al. A review of animal models of intervertebral disk degeneration: pathophysiology, regeneration, and translation to the clinic. Spine. 2011; 36: 1519-27. CrossRef

De Bari C, Dell'Accio F, Tylzanowski P, Luyten FP. Multipotent mesenchymal stem cells from adult human synovial membrane. Arthritis Rheum. 2001; 44(8): 1928-42. CrossRef

Detamore M, Athanasiou K. Motivation, characterization, and strategy for tissue engineering the temporomandibular joint disc. Tissue Eng. 2003; 9: 1065-87. CrossRef

Ding Z, Huang H. Mesenchymal stem cells in rabbit meniscus and bone marrow exhibit a similar feature but a heterogeneous multi-differentiation potential: superiority of meniscus as a cell source for meniscus repair. BMC Musculoskeletal Disorders. 2015; 16: 65-6. CrossRef

Fellows CR, Matta C, Zakany R, et al. Adipose, bone marrow and synovial joint-derived mesenchymal stem cells for cartilage repair. Front Genet [Internet]. 2016 [cited 24.04.2019]; 7: 23. Avaluable from: https://www.frontiersin.org/articles/10.3389/fgene.2016.00213/full CrossRef

Feng Y Egan B Wang J. Genetic factors in intervertebral disk degeneration. Genes Dis. 2016;3:178-85. CrossRef

Giri TK, Alexander A, Agrawal M, Ajazuddin S. Current status of stem cell therapies in tissue repair and regeneration. Curr Stem Cell Res Ther. 2018; 13(7): 1-10.

Gómez-Aristizábal A, Sharma A, Bakooshli MA, et al. Stage-specific differences in secretory profile of mesenchymal stromal cells (MSCs) subjected to early- vs late-stage OA synovial fluid. Osteoarthritis Cartilage. 2017; 25: 737-41. CrossRef

Gurruchaga H, Saenz del Burgo L, Garate A, et al. Cryopreservation of human mesenchymal stem cells in an allogeneic bioscaffold based on platelet rich plasma and synovial fluid. Sci Rep. [Internet]. 2017 Nov 16 [cited 24.04.2019]; 7:15733. Available from: https://www.nature.com/articles/s41598-017-16134-6 CrossRef

Hatsushika D, Muneta T, Nakamu T, et al. Repetitive allogeneic intraarticular injections of synovial mesenchymal stem cells promote meniskus regeneration in a porcine massive meniscus defect model. Osteoarthritis Cartilage. 2014;22: 941-50. CrossRef

Hilkens P, Driesen RB, Wolfs E, et al. Cryopreservation and banking of dental stem cells. Adv Exp Med Biol. 2016; 951: 199-235. CrossRef

Hoffman RM, Kajiura S, Cao W, et al. Cryopreservation of hair-follicle associated pluripotent (hap) stem cells maintains differentiation and hair-growth potential. Adv Exp Med Biol. 2016; 951: 191-8. CrossRef

Hunter CJ, Matyas JR, Duncan NA. Cytomorphology of notochondral and chondrocytic cells from the nucleus pulposus: a species comparison. J Anat. 2004; 205: 357-62. CrossRef

Hwang S, Kim SY, Park SH, et al. Human inferior turbinate: an alternative tissue source of multipotent mesenchymal stromal cells. Otolaryngol Head Neck Surg. 2012; 147: 568-74. CrossRef

Imai Y, Okuma M, An HS, et al. Restoration of disc height loss by recombinant human osteogenic protein-1 injection into intervertebral discs undergoing degeneration induced by an intradiscal injection of chondroitinase ABC. Spine. 2007; 32: 1197-205. CrossRef

Jiang Y, Tuan R. Origin and function of cartilage stem/progenitor cells in osteoarthritis. Nat Rev Rheumatol. 2015; 11: 206-12. CrossRef

Jiang Y, Cai Y, Zhang W, et al. Human cartilage-derived progenitor cells from committed chondrocytes for efficient cartilage repair and regeneration. Stem Cells Trans Med. 2016; 5: 733-44. CrossRef

Johnson VL, Hunter DJ. The epidemiology of osteoarthritis. Best Pract Res Clin Rheumatol. 2014; 28: 5-15. CrossRef

Johnstone B, Alini M, Cucchiarini M, et al. tissue engineering for articular cartilage repair - the state of the art. European Cells and Materials. 2013; 25: 248-67. CrossRef

Kahn D, Les C, Xia Y. Effects of cryopreservation on the depth-dependent elastic modulus in articular cartilage and implications for osteochondral grafting. J Biomech Eng. 2015; 137(5): 54-9. CrossRef

Kasai N, Mera H, Wakitani S, et al. Effect of epigallocatechin-3-o-gallate and quercetin on the cryopreservation of cartilage tissue. Biosci Biotechnol Biochem. 2017; 81(1): 192-9. CrossRef

Katz JN. Lumbar disk disorders and low-back pain: socioeconomic factors and consequences. J Bone Joint Surg Am. 2006; 88(2): 21-4. CrossRef

Kim J, Song D, Kim S, et al. Development and characterization of various osteoarthritis models for tissue engineering. PLoS ONE [Internet]. 2018 Mar 13 [cited 24.07.2018]; 13(3):e0194288. Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194288 CrossRef

Kimura T, Nakata K, Tsumaki N, et al. Progressive degeneration of articular cartilage and intervertebral discs. An experimental study in transgenic mice bearing a type IX collagen mutation. Int Orthopaedics. 1996; 20(3): 177-81. CrossRef

Kobayashi S, Takebe T, Inuia M, et al. Reconstruction of human elastic cartilage by a CD44+ CD90+ stem cell in the ear perichondrium. Proc Natl Acad Sci U S A. 2011; 108: 14479-84. CrossRef

Kobayashi S, Takebe T, Zheng Y, et al. Presence of cartilage stem/progenitor cells in adult mice auricular perichondrium. PLoS ONE [Internet]. 2011 Oct 19 [cited 03.06.2018]; 6(10):e26393. Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0026393 CrossRef

Lampropoulou-Adamidou K, Lelovas P, Karadimas EV, et al. Useful animal models for the research of osteoarthritis. Eur J Orthop Surg Traumatol. 2014; 24: 263-71. CrossRef

Lee WY, Wang B. Cartilage repair by mesenchymal stem cells: Clinical trial update and perspectives. J Orthop Translant. 2017; 9: 76-88. CrossRef

Levillain A, Boulocher C, Kaderli S, et al. Meniscal biomechanical alterations in ACLT rabbit model of early osteoarthritis. Osteoarthritis Cartilage. 2015; 23: 1186-93. CrossRef

Little C, Smith M. Animal models of osteoarthritis. Cur Rheumatol Rev. 2008, 4: 1-8. CrossRef

Luo S, Shi Q, Zha Z, et al. Morphology and mechanics of chondroid cells from human adipose-derived stem cells detected by atomic force microscopy. Mol Cell Biochem. 2012; 365: 223-31. CrossRef

Maerz T, Herkowitz H, Baker K. Molecular and genetic advances in the regeneration of the intervertebral disc. Surg Neurol Int. 2013; 4(2): S94-S105. CrossRef

Marquez-Curtis LA, Janowska-Wieczorek A, McGann LE, et al. Mesenchymal stromal cells derived from various tissues: biological, clinical and cryopreservation aspects. Cryobiology. 2015; 71(2): 181-97. CrossRef

Masahiro T, Sakai D, Hiyama A, et al. Effect of Cryopreservation on canine and human activated nucleus pulposus cells: a feasibility study for cell therapy of the intervertebral disc. Biores Open Access. 2013; 2(4): 273-82. CrossRef

Mastbergen SC, Marijnissen AC, Vianen ME, et al. The canine 'groove' model of osteoarthritis is more than simply the expression of surgically applied damage. Osteoarthritis Cartilage. 2006;14: 39-46. CrossRef

Mathijs GA, de Vries M, Bennink MB. Functional tissue analysis reveals successful cryopreservation of human osteoarthritic synovium. PLoS One [Internet]. 2016 Nov 21 [cited 24.04.2019]; 11(1):e0167076. Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0167076 CrossRef

Mazor M, Cesaro A, Ali M, Best TM, et al. Progenitor cells from cartilage: grade specific differences in stem cell marker expression. Int J Mol Sci. 2017;18:1759-60. CrossRef

McCoy AM. Animal models of osteoarthritis: comparisons and key considerations. Vet Pathol. 2015;52:803-18. CrossRef

McGonagle D, Baboolal TG, Jones E. Native joint-resident mesenchymal stem cells for cartilage repair in osteoarthritis. Nat Rev Rheumatol. 2017;12:719-30. CrossRef

Morrison KA, Cohen BP, Asanbe O, et al. Optimizing cell sourcing for clinical translation of tissue engineered ears. Biofabrication. 2016;9:015-19. CrossRef

Nam BM, Kim BY, Jo YH, et al. Effect of cryopreservation and cell passage number on cell preparations destined for autologous chondrocyte transplantation. Transplant Proc. 2014; 46(4): 1145-9. CrossRef

Nam Y, Rim Y, Lee J, Ju J. Current therapeutic strategies for stem cell-based cartilage regeneration. Stem Cells Int [Internet]. 2018 [cited 03.06.2018]; 2018: 8490489. Available from: https://www.hindawi.com/journals/sci/2018/8490489/ CrossRef

Oldershaw RA. Cell sources for the regeneration of articular cartilage: the past, the horizon and the future. Int J Exp Pathol. 2012;93:389-400. CrossRef

Otto IA, Levato R, Webb WR, et al. Progenitor cells in auricular cartilage demonstrate cartilage-forming capacity in 3D hydrogel culture. Eur Cell Mater. 2018; 35: 132-50. CrossRef

Pattappa G, Zhen Li, Peroglio M, et al. Diversity of intervertebral disc cells: phenotype and function. J Anat. 2012; 221: 480-96. CrossRef

Perdikakis E, Karachalios T, Katonis P, Karantanas A Comparison of MR-arthrography and MDCT-arthrography for detection of labral and articular cartilage hip pathology. Skeletal Radiol. 2011; 40: 1441-7. CrossRef

Rizk A, Rabie AB. Human dental pulp stem cells expressing transforming growth factor β3 transgene for cartilage-like tissue engineering. Cytotherapy. 2013; 5: 712-25. CrossRef

Rodrigues-Pinto R, Richardson SM, Hoyland JA. An understanding of intervertebral disc development, maturation and cell phenotype provides clues to direct cell-based tissue regeneration therapies for disk degeneration. Eur Spine J. 2014; 23: 1803-14. CrossRef

Rusu E, Necula L, Neagu A, Al,ecu M, Stan C, Albulescu R, Tanase C. Current status of stem cell therapy: Opportunities and limitations. Turk J Biol 2016; 40: 955-67. CrossRef

Sahlman J, Inkinen R, Hirvonen T, Lammi MJ Premature vertebral endplate ossification and mild disc degeneration in mice after inactivation of one allele belonging to the gene for Type II collagen. Spine. 2001; 26(23): 2558-65. CrossRef

Sekiya I, Ojima M, Suzuki S et al. Human mesenchymal stem cells in synovial fluid increase in the knee with degenerated cartilage and osteoarthritis. J Orthop Res. 2012; 30(6): 943-9. CrossRef

Shen W, Chen J, Zhu T, et al. Intra-articular injection of human meniscus stem/progenitor cells promotes meniscus regeneration and ameliorates osteoarthritis through stromal cell-derived factor-1/cxcr4-mediated homing. Stem Cells Trans Med. 2014; 3: 387-94. CrossRef

Singh K, Masuda K, An HS. Animal models for human disc degeneration. Spine J. 2005;6:267S-279S. CrossRef

Sriuttha W, Uttamo N, Kongkaew A. Ex vivo and in vivo characterization of cold preserved cartilage for cell transplantation. Cell Tissue Bank. 2016; 17(4): 721-34. CrossRef

Stoddart MJ, Bara J, Alini M. Cells and secretome - towards endogenous cell re-activation for cartilage repair. Adv Drug Deliv Rev. 2015; 84: 135-45. CrossRef

Sun Y, Zhang G, Liu Q, et al. Chondroitin sulfate from sturgeon bone ameliorates pain of osteoarthritis induced by monosodium iodoacetate in rats. Int J Biol Macromol. 2018; 117: 95-101. CrossRef

Tang R, Jing L, Willard V, et al. Differentiation of human induced pluripotent stem cells into nucleus pulposus-like cells. Stem Cell Research & Therapy. 2018; 9: 61-3. CrossRef

Tani Y, Sato M, Maehara M, et al. The effects of using vitrified chondrocyte sheets on pain alleviation and articular cartilage repair. J Tissue Eng Regen Med. 2017; 11(12): 3437-44. CrossRef

Vangsness CT Jr, Higgs G, Hoffman JK. Implantation of a novel cryopreserved viable osteochondral allograft for articular cartilage repair in the knee. J Knee Surg. 2018; 31(6): 528-35. CrossRef

Volkova N, Yukhta M, Goltsev A. Cryopreserved mesenchymal stem cells stimulate regeneration in an intervertebral disc. Biomed. 2015;3: 237-47. CrossRef

Wei X, Yang X, Han Z, Shao Q, et al. Mesenchymal stem cells: a new trend for cell therapy. Acta Pharmacologica Sinica. 2013;34:747-54. CrossRef

Wu L, Prins HJ, Helder MN, et al. Trophic effects of mesenchymal stem cells in chondrocyte co-cultures are independent of culture conditions and cell sources. Tissue Eng Part A. 2012; 18: 1542-51. CrossRef

Yan J, Tian F, Wang W, et al. Age dependent changes in cartilage matrix, subchondral bone mass, and estradiol levels in blood serum, in naturally occurring osteoarthritis in guinea pigs. Int J Mol Sci. 2014; 15: 13578-95. CrossRef

Yang N, Nayeb-Hashemi H, Canavan PK. The combined effect of frontal plane tibiofemoral knee angle and meniscectomy on the cartilage contact stresses and strains. Ann Biomed Eng. 2009; 37: 2360-72. CrossRef

Yong KW, Choi JR, Wan Safwani WK. Biobanking of human mesenchymal stem cells: future strategy to facilitate clinical applications. Adv Exp Med Biol. 2016; 951: 99-110. CrossRef

Yong KW, Wan Safwani WK, xu f. cryopreservation of human mesenchymal stem cells for clinical applications: current methods and challenges. Biopreserv Biobank. 2015; 13(4): 231-9. CrossRef

Zellner J, Pattappa G, Koch M, et al. Autologous mesenchymal stem cells or meniscal cells: what is the best cell source for regenerative meniscus treatment in an early osteoarthritis situation? Stem Cell Res Ther. 2017; 8: 225-31. CrossRef

Zhang Y, Drapeau S, An H, et al. Histological features of the degenerating intervertebral disc in a goat disc-injury model. Spine. 2001; 26: 2558-65. CrossRef

Zhao Z, Zhou X, Guan J, et al. Stem cells and chondrocytes increase the viability of chondrocytes in rat chondral defects. Oncol Let. 2018; 15: 7021-7. CrossRef

Zimmerlin L, Park T, Zambidis E, et al. Mesenchymal stem cell secretome and regenerative therapy after cancer. Biochimie. 2013; 95: 2235-45. CrossRef

Published

2019-12-17

How to Cite

Chaikovsky, Y. B., Herashchenko, S. B., & Deltsova, O. I. (2019). Problems and Perspectives of Using Stem Cells of Cartilage Tissues. Problems of Cryobiology and Cryomedicine, 29(4), 303-316. https://doi.org/10.15407/cryo29.04.303