Structural and Functional Effect Mechanisms of Extreme Cooling on Hypothalamus Thermoregulatory Centers
Keywords:extreme cooling, cryotherapy, hypothermia, blood brain barrier, hypothalamus, ultrastructure
The authors studied the central structural and functional effect mechanisms of periodic short term organism cooling in cryochamber (-120°C). There has been demonstrated a periodic increase of blood brain barrier (BBB) permeability stipulated by a long-term activation of the neurons’ synaptic apparatus of pre-optic hypothalamus area. There were presented the suppositions on the relation of cryotherapy therapeutic effect with the increase of functional activity in neurotransmitter-cyclic mononucleosides-retrograde messengers (NO, CO) system which effect was unified at the level of cytolemma and receptor-cytoskeleton complex.
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