Structural and Functional Effect Mechanisms of Extreme Cooling on Hypothalamus Thermoregulatory Centers

Authors

  • V. G. Babijchuk Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • V. S. Marchenko Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • G. A. Babijchuk Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • L. N. Marchenko Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • T. I. Bondar Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Keywords:

extreme cooling, cryotherapy, hypothermia, blood brain barrier, hypothalamus, ultrastructure

Abstract

The authors studied the central structural and functional effect mechanisms of periodic short term organism cooling in cryochamber (-120°C). There has been demonstrated a periodic increase of blood brain barrier (BBB) permeability stipulated by a long-term activation of the neurons’ synaptic apparatus of pre-optic hypothalamus area. There were presented the suppositions on the relation of cryotherapy therapeutic effect with the increase of functional activity in neurotransmitter-cyclic mononucleosides-retrograde messengers (NO, CO) system which effect was unified at the level of cytolemma and receptor-cytoskeleton complex.

Published

2004-06-15

How to Cite

Babijchuk, V. G., Marchenko, V. S., Babijchuk, G. A., Marchenko, L. N., & Bondar, T. I. (2004). Structural and Functional Effect Mechanisms of Extreme Cooling on Hypothalamus Thermoregulatory Centers. Problems of Cryobiology and Cryomedicine, (2), 62-70. Retrieved from http://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/690

Issue

Section

Theoretical and Experimental Cryobiology