Cancer Stem Cells in Tumor Pathogenesis after Cryoablation


  • Anatoliy N. Goltsev Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • Olga A. Diabina Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • Maksim V. Ostankov Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • Nikolay A. Bondarovich Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • Ekaterina Ye. Yampolskaya Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov



malignancy, cancer stem cells, cryoablation


The review highlights some areas of malignant tumor treatment, particularly the cryosurgery of solid tumors. There is discussed the possibility of using the method of cryoablation as a tool for targeting and inactivation of cancer stem cells, being the main structural unit, initiating, maintaining growth and tumor metastasis. The publications regarding the phenotypic and functional characteristics of tumor-inducing cells, including both more potent CSCs and advanced in the differentiation of their descendants, the nature of cold factor impact on them were analyzed. The main ways to optimize the use of cryoablation technique in clinical practice are under consideration.

Probl Cryobiol Cryomed 2015; 25(3):205-218

Author Biographies

Anatoliy N. Goltsev, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Department of Cryopathophysiology and Immunology

Olga A. Diabina, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Department of Cryopathophysiology and Immunology

Maksim V. Ostankov, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Department of Cryopathophysiology and Immunology

Nikolay A. Bondarovich, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Department of Cryopathophysiology and Immunology

Ekaterina Ye. Yampolskaya, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Department of Cryopathophysiology and Immunology


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How to Cite

Goltsev, A. N., Diabina, O. A., Ostankov, M. V., Bondarovich, N. A., & Yampolskaya, E. Y. (2015). Cancer Stem Cells in Tumor Pathogenesis after Cryoablation. Problems of Cryobiology and Cryomedicine, 25(3), 205–218.