Cardioprotective Effect of Low Molecular Weight (Below 5 kDa) Fraction of Cattle Cord Blood Cryohemolysate

Authors

DOI:

https://doi.org/10.15407/cryo32.03.206

Keywords:

myocardial infarction, model, hyperlipidemia, hypoxia, low molecular weight fraction of cord blood, Actovegin

Abstract

In this report, we have studied a cardioprotective effect of low molecular weight (below 5 kDa) fraction derived from cattle cord blood in a rat model of infarction-like cardiovasopathy. The myocardial infarction development was initiated in the animals, maintained for two months on a diet with excessive intake of fat, calcium and sodium salts, by making hypoxia-hypercapnia in them. The use of this model allowed inducing the infarction-like cardiovasopathy, comparable by many respects with the clinical picture of myocardial infarction, which was confirmed by electrocardiography, enzyme-linked immunosorbent assay and histological analysis. Preliminary administration of low molecular weight (below 5 kDa) fraction of cattle cord blood, as well as Actovegin did not prevent the heart attack, but increased the endurance of rats to hypoxia-hypercapnia and reduced the damage rate to myocardium. A preventive administration of low molecular weight fraction of cord blood was proven to mitigate the risk of hypoxia-induced damages to myocardium.

 

Probl Cryobiol Cryomed 2022; 32(3):206–213

Author Biographies

Ivan І. Shcheniavsky, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv

Department of Cold Adaptation

Igor F. Kovalenko, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv

Department of Low-Temperature Preservation

Oleksandr K. Gulevsky, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv

Department of Cold Adaptation

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Published

2022-09-30

How to Cite

Shcheniavsky, I., Kovalenko, I., & Gulevsky, O. (2022). Cardioprotective Effect of Low Molecular Weight (Below 5 kDa) Fraction of Cattle Cord Blood Cryohemolysate. Problems of Cryobiology and Cryomedicine, 32(3), 206–213. https://doi.org/10.15407/cryo32.03.206

Issue

Section

Theoretical and Experimental Cryobiology