Rhythmic Cold Effect on Activity of Elastases in Female Rats with Alcohol-Dependent Hypertension

Authors

  • L. M. Samokhina L.T. Malaya Institute of Therapy of Academy of Medical Sciences of Ukraine, Kharkov
  • N. F. Starodub National University of Bioresourses and Environmental Management of Ukraine, Kiev
  • G. A. Babiychuk Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • V. V. Lomako Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Keywords:

rhythmic cold exposure, alcohol-dependent hypertension, elastase, metalloelastase, elastase-like activity of cysteine proteinases, αlpha-1- proteinase inhibitor, females

Abstract

Under the influence of rhythmic cold exposures (RCEs) in female rats with alcohol-dependent hypertension there was found a suppressed activity of elastases of different origin in tissues of brain cortex, lungs, heart, liver and kidneys lower than the control level. RCEs lead to oppositely directed changes in elastase-inhibitory activity (EIA) of alpha-1- proteinase inhibitor ( alpha-1-PI) caused by alcohol effect and namely to the rise in all the studied tissues except kidneys wherein there was found a decrease. Herewith if compared to the control EIA alpha-1-PI increased only in lungs and liver, i. e. in the sites of possible synthesis of this inhibitor. The absence of stimulating an inhibitory potential in brain cortex and heart is in accordance with local decrease of EIA alpha-1-PI in the control and may be stipulated with the fact that inhibitor does not enter from the synthesis sites.

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Published

2024-05-21

How to Cite

Samokhina, L. M., Starodub, N. F., Babiychuk, G. A., & Lomako, V. V. (2024). Rhythmic Cold Effect on Activity of Elastases in Female Rats with Alcohol-Dependent Hypertension. Problems of Cryobiology and Cryomedicine, 22(1), 49–60. Retrieved from http://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/97

Issue

Vol. 22 No. 1 (2012): Problems of Cryobiology

Section

Theoretical and Experimental Cryobiology

License

Copyright (c) 2020 L. M. Samokhina, N. F. Starodub, G. A. Babiychuk, V. V. Lomako

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