Comparative Evaluation of Wound Healing Effect of Cord Blood Low Molecular Weight Fraction (Below 5 kDa) and Actovegin Drug in Skin Cryolesions

Авторы

  • Oleksandr Gulevsky Институт проблем криобиологии и криомедицины НАН Украины, г. Харьков http://orcid.org/0000-0002-4676-3375
  • Nataliia Moisieieva Институт проблем криобиологии и криомедицины НАН Украины, г. Харьков
  • Olga Gorina Институт проблем криобиологии и криомедицины НАН Украины, г. Харьков http://orcid.org/0000-0003-4075-650X
  • Yuliya Akhatova Институт проблем криобиологии и криомедицины НАН Украины, г. Харьков https://orcid.org/0000-0002-1536-6924

DOI:

https://doi.org/10.15407/cryo31.02.116

Ключевые слова:

cryoablation, cord blood, Actovegin, rats, wound surface

Аннотация

This paper presents the results of comparative studies of the impact of the low molecular weight (below 5 kDa) cattle cord blood fraction (CBF) and the comparator drug Actovegin on tissue regeneration after skin cryoablation in rats. Here, a local contact cryoexposure was shown to result not only in destruction of all skin layers, but secondary ischemic damage to deeper and adjacent tissues as well. The use of an injection solution of CBF as a therapy for simulated cryolesion proved its pronounced wound healing effect, manifested in accelerated reparation, improved trophicity in an injured area due to hypervascularization and prevention of sclerotic processes. The introduction of CBF and Actovegin to rats accelerated the normalization of clinical blood parameters (RBC and WBC counts, alkaline phosphatase activity) in shorter terms as compared with the control. The obtained effect may be compared with Actovegin action.

 

Probl Cryobiol Cryomed 2021; 31(2): 116–126

 

Биографии авторов

Oleksandr Gulevsky, Институт проблем криобиологии и криомедицины НАН Украины, г. Харьков

Department of Cold Adaptation

Nataliia Moisieieva, Институт проблем криобиологии и криомедицины НАН Украины, г. Харьков

Department of Cold Adaptation

Olga Gorina, Институт проблем криобиологии и криомедицины НАН Украины, г. Харьков

Department of Cold Adaptation

Yuliya Akhatova, Институт проблем криобиологии и криомедицины НАН Украины, г. Харьков

Department of Cold Adaptation

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Загрузки

Опубликован

2021-07-15

Как цитировать

Gulevsky, O., Moisieieva, N., Gorina, O., & Akhatova, Y. . (2021). Comparative Evaluation of Wound Healing Effect of Cord Blood Low Molecular Weight Fraction (Below 5 kDa) and Actovegin Drug in Skin Cryolesions. Проблемы криобиологии и криомедицины, 31(2), 116–126. https://doi.org/10.15407/cryo31.02.116

Выпуск

Раздел

Теоретическая и экспериментальная криобиология