Cryopreservation as Biotechnological Application of Dendritic Cells in Clinical Practice

Авторы

  • Anatoliy Goltsev Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv; Interdepartmental Scientific Center of the National Academy of Sciences of Ukraine, Academy of Medical Sciences of Ukraine and Ministry of Health of Ukraine, Kharkiv https://orcid.org/0000-0002-5289-5876
  • Katerina Yampolska Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv https://orcid.org/0000-0002-5138-3385
  • Hanna Kisielova Институт проблем криобиологии и криомедицины НАН Украины, г. Харьков
  • Maksym Оstankov Институт проблем криобиологии и криомедицины НАН Украины, г. Харьков https://orcid.org/0000-0001-8412-5262
  • Tatiana Dubrava Институт проблем криобиологии и криомедицины НАН Украины, г. Харьков https://orcid.org/0000-0002-1056-5107
  • Natalya Babenko Институт проблем криобиологии и криомедицины НАН Украины, г. Харьков https://orcid.org/0000-0001-7002-0267
  • Yuliya Gaevska Институт проблем криобиологии и криомедицины НАН Украины, г. Харьков https://orcid.org/0000-0002-2375-357X
  • Mykola Bondarovych Институт проблем криобиологии и криомедицины НАН Украины, г. Харьков https://orcid.org/0000-0001-7977-0283

DOI:

https://doi.org/10.15407/cryo31.04.289

Ключевые слова:

cryopreservation, mononuclear cells, monocytes, tolerogenic dendritic cells, autoimmune diseases

Аннотация

An important component of the pathogenesis of autoimmune diseases is the immune system deregulation as an impaired tolerance to its own antigens by reducing the content of T-regulatory cells. Their formation is closely related to the function of dendritic cells (DCs), so in autoimmune diseases the use of DCs with tolerogenic potential is promising for the restoration of antigen-specific tolerance. Recently, the issue of establishing the banks of tolerogenic DCs for clinical use, which involves their cryopreservation, has been actively discussed. To date, there is no common  protocol for DCs freezing, which would take into account the different sources of their obtaining,  the initial structural and functional state before freezing, composition of cryopreservation media and other factors. The review summarizes experimental data on cryopreservation of peripheral blood and bone marrow mononuclear cells or monocytes. The potential for their further ex vivo differentiation into  DCs to ensure the stability of immature phenotype and tolerogenic function has been studied.

Probl Cryobiol Cryomed 2021; 31(4): 289–303

Биографии авторов

Anatoliy Goltsev , Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv; Interdepartmental Scientific Center of the National Academy of Sciences of Ukraine, Academy of Medical Sciences of Ukraine and Ministry of Health of Ukraine, Kharkiv

Department of Cryopatophysiology and Immunology

Katerina Yampolska, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv

Department of Cryopatophysiology and Immunology

Hanna Kisielova, Институт проблем криобиологии и криомедицины НАН Украины, г. Харьков

Department of Cryopatophysiology and Immunology

Maksym Оstankov , Институт проблем криобиологии и криомедицины НАН Украины, г. Харьков

Department of Cryopatophysiology and Immunology

Tatiana Dubrava , Институт проблем криобиологии и криомедицины НАН Украины, г. Харьков

Department of Cryopatophysiology and Immunology

Natalya Babenko, Институт проблем криобиологии и криомедицины НАН Украины, г. Харьков

Department of Cryopatophysiology and Immunology

Yuliya Gaevska, Институт проблем криобиологии и криомедицины НАН Украины, г. Харьков

Department of Cryopatophysiology and Immunology

Mykola Bondarovych, Институт проблем криобиологии и криомедицины НАН Украины, г. Харьков

Department of Cryopatophysiology and Immunology

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Опубликован

2021-12-24

Как цитировать

Goltsev , A., Yampolska, K., Kisielova, H., Оstankov M., Dubrava , T., Babenko, N., Gaevska, Y., & Bondarovych, M. (2021). Cryopreservation as Biotechnological Application of Dendritic Cells in Clinical Practice. Проблемы криобиологии и криомедицины, 31(4), 289–303. https://doi.org/10.15407/cryo31.04.289

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Обзорные статьи