On the Mechanism of Osmotic Protection of Erythrocytes. I. Model of Osmometer

Authors

  • S. V. Rudenko Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • E. M. Shchetinina V.N.Karazin Kharkov National University, Kharkov
  • E. L. Volovelskaya Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Keywords:

erythrocytes, hypotonic hemolysis, osmotic protection, osmotic behavior

Abstract

The properties of simple model of osmotic balance in erythrocytes involving the contributions of intracellular electrolytes and non-ideal osmotic properties of hemoglobin were investigated. Analyzing this model we suggested two mechanisms that may take part in the rise of erythrocyte resistance to hypotonic media induced by different agents. One mechanism is associated with protecting release of intracellular electrolytes, in particular, chloride anions, the second one is associated with the change of intracellular osmolarity presumably due to degradation of hemoglobin tetramers into dimers with a simultaneous redistribution of intracellular electrolytes. The ways for experimental testing of the suggested mechanisms have been shown.

Downloads

Published

2011-12-19

How to Cite

Rudenko, S. V., Shchetinina, E. M., & Volovelskaya, E. L. (2011). On the Mechanism of Osmotic Protection of Erythrocytes. I. Model of Osmometer. Problems of Cryobiology and Cryomedicine, 21(4), 377–385. Retrieved from https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/109

Issue

Vol. 21 No. 4 (2011): Problems of Cryobiology

Section

Theoretical and Experimental Cryobiology

License

Copyright (c) 2020 S. V. Rudenko, E. M. Shchetinina, E. L. Volovelskaya

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

  • Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  • Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  • Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).