Umbilical cord blood stem cells: clinical application of allogeneic material, problems and perspectives of banking
Keywords:umbilical cord blood, hematopoietic stem cells, mesenchymal stromal stem cells, allogeneic transplantation, cryopreservation, public umbilical cord blood banks, standards, biomedical ethics
Abstract: Human umbilical cord blood (UCB) is an important source of hematopoietic stem cells (HSCs), successfully used for allogeneic transplantation to treat a wide range of serious diseases. This article discusses a number of topical problems associated with the functioning of public low-temperature banks of UCB. The principles of standardization, quality control and the effective selection of the cryopreserved units at the transplant centers request are considered from the point of view of the world transplantation practice for this unique biological material. The issues related to the trends in therapy using mesenchymal stromal/stem cells from the fetoplacental complex tissues and their cryopreservation are also deliberated. Special attention is paid to the issues of biomedical ethics and the prospects of public UCB bank establishing in Ukraine, its role in the development of the national HSCs unrelated transplantation.
Probl Cryobiol Cryomed 2020; 30(3): 213–235
Abazari A, Meimetis LG, Budin G, et al. Engineered trehalose permeable to mammalian cells. PLOS ONE [Internet]. 2015 June 26 [cited 2017 Aug 15];10(6):e0130323. Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0130323. CrossRef
Akkok CA, Holte MR, Tangen JM, et al. Hematopoietic engraftment of dimethyl sulfoxide-depleted autologous peripheral blood progenitor cells. Transfusion. 2009;49(2):354-61. CrossRef
Aljurf M, Weisdorf D, Hashmi S, et al. Worldwide Network for Blood and Marrow Transplantation recommendations for establishing a hematopoietic stem cell transplantation program in countries with limited resources, part I: clinical, technical, and socioeconomic considerations. Biol Blood Marrow Transplant. 2019;25(12):2330-7. CrossRef
Anand S, Thomas S, Corbet K, et al. Adult umbilical cord blood transplantation using myeloablative thiotepa, total body irradiation, and fludarabine conditioning. Biol Blood Marrow Transplant. 2017;23(11):1949-54. CrossRef
Arutyunyan I, Fatkhudinov T, Sukhikh G. Umbilical cord tissue cryopreservation: a short review. Stem Cell Res Ther [Internet]. 2018 Sep 15 [cited 2019 Nov 20];9(1):236. Available from: https://stemcellres.biomedcentral.com/articles/10.1186/s13287-018-0992-0 CrossRef
Awan M, Buriak I, Fleck R, et al. Dimethyl sulfoxide: a central player since the dawn of cryobiology, is efficacy balanced by toxicity? Regen Med. 2020;15(3):1463-91. CrossRef
Babijchuk LA, Mykhailova OO, Ryazantsev VV, et al. Cryopreservation of cord blood nucleated cells using non-penetrating cryoprotectant PEO-1500. Probl Cryobiol Cryomed. 2016;26(1):24-34. CrossRef
Badowski M, Muise A, Harris DT. Mixed effects of long-term frozen storage on cord tissue stem cells. Cytotherapy. 2014;16(9):1313-21. CrossRef
Ballen K. Update on umbilical cord blood transplantation. F1000Res [Internet]. 2017 Aug 24[cited 2018 Feb 14];6 :1556. Available from: https://f1000research.com/articles/6-1556/v1 CrossRef
Barker JN, Byam CE, Kernan NA, et al. Availability of cord blood extends allogeneic hematopoietic stem cell transplant access to racial and ethnic minorities. Biol Blood Marrow Transplant. 2010;16(11):1541-8. CrossRef
Barker JN, Scaradavou A, Stevens CE. Combined effect of total nucleated cell dose and HLA match on transplantation outcome in 1061 cord blood recipients with hematologic malignancies. Blood. 2010;115(9):1843-9. CrossRef
Bart T, Boo M, Balabanova S, et al. Impact of selection of cord blood units from the United States and Swiss registries on the cost of banking operations. Transfus Med Hemother. 2013;40(1):14-20. CrossRef
Bautista G, Cabrera JR, Regidor C, et al. Cord blood transplants supported by co-infusion of mobilized hematopoietic stem cells from a third-party donor. Bone Marrow Transplant. 2009;43(5):365-73. CrossRef
Belous AM, Grishchenko VI. [Cryobiology]. Kyiv: Naukova Dumka; 1994. 432 p. Russian.
Belous AM, Shrago MI, Pushkar NS. [Cryopreservatives]. Kyiv: Naukova Dumka; 1979. 200 p. Russian.
Bissoyi A, Pramanik K. Effects of non-toxic cryoprotective agents on the viability of cord blood derived MNCs. Cryo Letters. 2013;34(5):453-65. PubMed
Brady C, Armitage S, Freed B, et al. How transplant centers deal with the dextran shortage: recommendations for comparing alternatives. Transfusion. 2016;56(11):2657-61. CrossRef
Broxmeyer HE, Douglas GW, Hangoc G, et al. Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells. Proc Natl Acad Sci USA. Medical Sciences. 1989; 86:3828-32. CrossRef
Brunstein CG, Fuchs EJ, Carter SL, et al. Alternative donor transplantation after reduced intensity conditioning: results of parallel phase 2 trials using partially HLA-mismatched related bone marrow or unrelated double umbilical cord blood grafts. Blood. 2011;118(2):282-8. CrossRef
Brunstein CG, Gutman JA, Weisdorf DJ, et al. Allogeneic hematopoietic cell transplantation for hematologic malignancy: relative risks and benefits of double umbilical cord blood. Blood. 2010;116(22):4693-9. CrossRef
Brunstein CG, Miller JS, Cao Q, et al. Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood. 2011;117(3):1061-70. CrossRef
Castillo N, García-Cadenas I, García O, et al. Few and nonsevere adverse infusion events using an automated method for diluting and washing before unrelated single cord blood transplantation. Biol Blood Marrow Transplant. 2015;21(4):682-7. CrossRef
Chatzistamatiou TK, Papassavas AC, Michalopoulos E, et al. Optimizing isolation culture and freezing methods to preserve Wharton's jelly's mesenchymal stem cell (MSC) properties: an MSC banking protocol validation for the Hellenic Cord Blood Bank. Transfusion. 2014; 54(12):3108-20. CrossRef
Chen G, Yue A, Ruan Zh, et al. Comparison of the effects of different cryoprotectants on stem cells from umbilical cord blood. Stem Cells International [Internet]. 2016 [cited 2017 Dec 20];2016: Article ID 1396783. Available from: https://www.hindawi.com/journals/sci/2016/1396783/ CrossRef
Choudhery MS, Badowski M, Muise A, Harris DT. Comparison of human mesenchymal stem cells derived from adipose and cord tissue. Cytotherapy. 2013;15(3):330-43. CrossRef
Cohen S, Roy J, Lachance S, Delisle JS, et al. Hematopoietic stem cell transplantation using single UM171-expanded cord blood: a single-arm, phase 1-2 safety and feasibility study. Lancet Haematol. 2020;7(2):e134-e145. CrossRef
Commission Directive 2006/17/EC of 8 February 2006 implementing Directive 2004/23/EC of the European Parliament and of the Council as regards certain technical requirements for the donation, procurement and testing of human tissues and cells (Text with EEA relevance) [Internet]. EUR-Lex. Access to European Unian Low 2019 [cited 2019 Dec 16]. Available from: https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=celex%3A32006L0017.
Commission Directive (EU) 2015/565 of 8 April 2015 amending Directive 2006/86/EC as regards certain technical requirements for the coding of human tissues and cells (Text with EEA relevance) [Internet]. EUR-Lex. Access to European Unian Low 2019 [cited 2019 Dec 16]. Available from: https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=celex:32015L0565
Crowe J, Crowe L, Oliver A, et al. The trehalose myth revisited: introduction to a symposium on stabilization of cells in the dry state. Cryobiology. 2001;43(2):89-105. CrossRef
Cuende N, Rasko JEJ, Koh MBC, et al. Cell, tissue and gene products with marketing authorization in 2018 worldwide. Cytotherapy. 2018;20(11):1401-13. CrossRef
Directive 2004/23/EC of the European Parliament and of the Council of 31 March 2004 on setting standards of quality and safety for the donation, procurement, testing, processing, preservation, storage and distribution of human tissues and cells [Internet]. EUR-Lex. Access to European Unian Low; 2019 [cited 2019 Dec 16]. Available from: https://eur-lex.europa.eu/eli/dir/2004/23/oj.
Eapen M, Klein JP, Ruggeri A, et al. Impact of allele-level HLA matching on outcomes after myeloablative single unit umbilical cord blood transplantation for hematologic malignancy. Blood. 2014;123(1):133-40. CrossRef
Eapen M, Rubinstein P, Zhang MJ, et al. Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study. Lancet. 2007;369(9577):1947-54. CrossRef
European Federation for Immunogenetics. Standards for histocompatibility & immunogenetics testing. Version 7.0 [Internet]. Effective from 1st January 2018 [cited 2018 Feb 25]; 40 p. Available from: https://www.efi-web.org/efi-committees/standards-committee.html#c273.
Feng M, Lu A, Gao H, et al. Safety of allogeneic umbilical cord blood stem cells therapy in patients with severe cerebral palsy: a retrospective study. Stem Cells Int [Internet]. 2015 [cited 2016 Feb 12]; 2015: Article ID 325652. Available from: https://www.hindawi.com/journals/sci/2015/325652/ CrossRef
Fois E, Desmartin M, Benhamida S, et al. Recovery, viability and clinical toxicity of thawed and washed haematopoietic progenitor cells: analysis of 952 autologous peripheral blood stem cell transplantations. Bone Marrow Transplant. 2007;40(9):831-5. CrossRef
Foundation for the Accreditation of Cellular Therapy (FACT), International Netcord Fundation. NetCord-FACT International Standards for Cord Blood Collection, Banking, and Release for Administration, 7th Edition, Oct 15, 2019; [Internet]. [cited 2019 Dec 16]. Available from: http://www.factwebsite.org/cbstandards/
Foundation for the Accreditation of Cellular Therapy (FACT), Joint Accreditation Committee - ISCT and EBMT (JACIE). International standards for hematopoietic cellular therapy product collection, processing, and administration, 7th Edition, 1 March 2018; [Internet]. EBMT; 2018 [cited 2019 Dec 16]. Available from: https://www.ebmt.org/sites/default/files/2018-06/FACT-JACIE%207th%20Edition%20Standards.pdf
Gluckman E. Chapter 6. Choice of the donor accoding to HLA typing and stem cell sourse. In: Apperley J, Carreras E, Gluckman E, Masszi T, editors. Haematopoietic Stem Cell Transplantation. The EBMT Handbook, 6th Edition. Genoa: Litoprint; 2012, p. 90-105.
Gluckman E, Rocha V. Donor selection for unrelated cord blood transplants. Curr Opin Immunol. 2006;18(5):565-70. CrossRef
Gluckman E, Ruggeri A, Volt F, et al. Milestones in umbilical cord blood transplantation. Br J Haematol. 2011;154(4):441-7. CrossRef
Goltsev AN, Gayevskaya YuA, Dubrava TG, Ostankova LV. Effect of cryopreservation on functional status of bone marrow hematopoietic and mesenchymal stem cells in animal with autoimmune pathology. Probl Cryobiol Cryomed. 2016;26(1):63-72. CrossRef
Goltsev AN, Volina VV, Ostankov MV, et al. Effect of cryopreservation on functional properties of human cord blood leukoconcentrate nucleated cells. Problems of Cryobiology. 2010;20(1):66-72.
Gragert L, Eapen M, Williams E, et al. HLA match likelihoods for hematopoietic stem-cell grafts in the U.S. registry. N Engl J Med. 2014; 371(14):339-48. CrossRef
Grischenko VI. [Achievements and prospects of cryobiology and cryomedicine development in Ukraine]. Problems of Cryobiology. 2005; 15(3):231-40. Russian. Full Text
Gulevskii AK, Bondarenko VA, Belous AM. [Barrier properties of biomembranes at low temperatures]. Kyiv: Naukova Dumka; 1988. 208 p. Russian.
Hanslick JL, Lau K, Noguchi KK, et al. Dimethyl sulfoxide (DMSO) produces widespread apoptosis in the developing central nervous system. Neurobiol Dis. 2009;34(1):1-10. CrossRef
Harris DT. Banking of adipose- and cord tissue-derived stem cells: technical and regulatory issues. Adv Exp Med Biol. 2016;951:147-54. CrossRef
Harris DT. Stem cell banking for regenerative and personalized medicine. Biomedicines. 2014;2(1):50-79. CrossRef
Hashmi SK, Srivastava A, Rasheed W, et al. Cost and quality issues in establishing hematopoietic cell transplant program in developing countries. Hematol Oncol Stem Cell Ther. 2017;10(4):167-72. CrossRef
Horacek JM, Jebavy L, Jakl M, et al. Cardiovascular changes associated with infusion of hematopoietic cell grafts in oncohematological patients-impact of cryopreservation with dimethylsulfoxide. Exp Oncol. 2009;31(2):121-2. PubMed
Horwitz ME, Chao NJ, Rizzieri DA, et al. Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment. J Clin Invest. 2014;124(7):3121-8. CrossRef
Hough R, Danby R, Russell N, et al. Recommendations for a standard UK approach to incorporating umbilical cord blood into clinical transplantation practice: an update on cord blood unit selection, donor selection algorithms and conditioning protocols. Br J Haematol. 2016;172(3): 360-70. CrossRef
Hunt CJ, Armitage SE, Pegg DE. Cryopreservation of umbilical cord blood: 2. Tolerance of CD34+ cells to multimolar dimethyl sulphoxide and the effect of cooling rate on recovery after freezing and thawing. Cryobiology. 2003;46(1):76-87. CrossRef
Isasi R, Dalpe G, Knoppers BM. Fostering public cord blood banking and research in Canada. Stem Cells Dev. 2013;22(Suppl 1):29-34. CrossRef
JACIE Accreditation [Internet]. EBMT; 2018 [updated 2018]; [cited 2019 Dec 9]. Available from: https://www.ebmt.org/jacie-accreditation.
Jaime-Pérez, G García-Arellano G, Esparza-Sandoval AC. What is the adequate mononuclear cell content for selecting umbilical cord blood units for cryopreservation? Rev Bras Hematol Hemoter. 2016;38(1):88-9. CrossRef
Junior AM, Arrais CA, Saboya R, et al. Neurotoxicity associated with dimethylsulfoxide-preserved hematopoietic progenitor cell infusion. Bone Marrow Transplant. 2008;41(1):95-6. CrossRef
Kalynychenko T, Anoshyna M, Balan V. [Advantages of umbilical cord blood hemopoietic tissue cryopreservation using an unit volume reduction optimized method]. Hematology. Transfusiology. Eastern Europe. 2017;3(4):734-43. Russian.
Kalynychenko T. [Prognostic assessment of cryosensitivity level for umbilical cord blood hemopoietic tissue with the help of markers of prooxidant activity processes]. Science-Rise: Medical Science. 2018;(5):52-8,70-2. Ukrainian. CrossRef
Kalynychenko TO. Ethical issues of research, banking and clinical application of human cord blood hematopoietic stem cells. Exp Oncol. 2017;39(3):244.
Kalynychenko TO. Umbilical cord blood banking in the worldwide hematopoietic stem cell transplantation system: perspectives for Ukraine. Exp Oncol. 2017;39(3):164-70. CrossRef
Katsen-Globa A, Meiser I, Petrenko YuA, et al. Towards ready-to-use 3-D scaffolds for regenerative medicine: adhesion-based cryopreservation of human mesenchymal stem cells attached and spread within alginate-gelatin cryogel scaffolds. J Mater Sci: Mater Med. 2014;25:857-71. CrossRef
Khomenko VI, Bychkov VV, Bazyka DA. [State of development of hematopoietic stem cell transplantation in Europe and the world]. Likars'ka sprava. 2014;(7-8):117-21. Ukrainian.
Kiernan J, Damien P, Monaghan M, et al. Clinical studies of ex vivo expansion to accelerate engraftment after umbilical cord blood transplantation: a systematic review. Transfus Med Rev. 2017;31(3):173-82. CrossRef
Kindzelsky LP, Zverkova AS, Sivkovich SA, et al. [Chapter 3. Features of treatment of victims due to the Chernobyl disaster. 3.3. Transfusion of bone marrow in the treatment of cytotoxic disease]. In: Kindzelsky LP, et al. editors. [Acute radiation sickness in the conditions of the Chernobyl disaster]. Kyiv: Teleoptik; 2002. P. 188-99. Russian.
Kurtzberg J, Prasad VK, Carter SL, et al. Results of the Cord Blood Transplantation Study (COBLT): clinical outcomes of unrelated donor umbilical cord blood transplantation in pediatric patients with hematologic malignancies. Blood. 2008;112(10):4318-27. CrossRef
Kurtzberg J, Prockop S, Teira P, et al. Allogeneic human mesenchymal stem cell therapy (remestemcel-L, Prochymal) as a rescue agent for severe refractory acute graft-versus-host disease in pediatric patients. Biol Blood Marrow Transplant. 2014;20(2):229-35. CrossRef
Lavrik S. [Cryopreservation of bone marrow]. Kyiv: Zdorovia, 1975: 87-95. Russian.
Li J, McDonald CA, Fahey MC, Jenkin G, Miller SL. Could cord blood cell therapy reduce preterm brain injury? Front Neurol [Internet]. 2014 Oct 9 [cited 2018 Feb 2]; 5:200. Available from: https://www.frontiersin.org/articles/10.3389/fneur.2014.00200/full. CrossRef
Liso A, Neri M, Maglietta F, et al. Hematopoietic stem cell transplantation: a bioethical lens. Stem Cells Int [Internet]. 2017 Jun 27 [cited 2019 Dec 20];2017: Article ID 1286246. Available from: https://www.hindawi.com/journals/sci/2017/1286246/ CrossRef
Laroche V, McKenna DH, Moroff G, Schierman T, Kadidlo D, McCullough J. Cell loss and recovery in umbilical cord blood processing: a comparison of postthaw and postwash samples. Transfusion. 2005;45(12):1909-16. CrossRef
Lown RN, Shaw BE. 'First do no harm': where do we stand on unrelated hematopoietic cell donor safety? Expert Rev Hematol. 2012;5(3):249-52. CrossRef
Marquez-Curtis LA, Janowska-Wieczorek A, McGann LE, Elliott JA. Mesenchymal stromal cells derived from various tissues: biological, clinical and cryopreservation aspects. Cryobiology. 2015;71(2):181-97. CrossRef
Martin PS, Li S, Nikiforow S, et al. Infused total nucleated cell dose is a better predictor of transplant outcomes than CD34+ cell number in reduced-intensity mobilized peripheral blood allogeneic hematopoietic cell transplantation. Haematologica. 2016;101(4):499-505. CrossRef
Martinetti D, Colarossi C, Buccheri S, et al. Effect of trehalose on cryopreservation of pure peripheral blood stem cells. Biomed Rep. 2017;6(3):314-8. CrossRef
Massin F, Huili C, Decot V, et al. Validation of a single-platform method for hematopoietic CD34+ stem cells enumeration according to accreditation procedure. Biomed Mater Eng. 2015;25(1 Suppl):27-39. CrossRef
Mastrolia I, Foppiani EM, Murgia A, et al. Challenges in clinical development of mesenchymal stromal/stem cells: concise review. Stem Cells Transl Med. 2019;8(11):1135-48. CrossRef
Medhekar SK, Shende VS, Chincholkar AB. Recent stem cell advances: cord blood and induced pluripotent stem cell for cardiac regeneration - a review. Int J Stem Cells. 2016;9(1):21-30. CrossRef
Milano F, Gooley T, Wood B, et al. Cord-blood transplantation in patients with minimal residual disease. N Engl J Med. 2016;375:944-53. CrossRef
Mohr A, Busby H, Hervey T, Dingwall R. Mapping the role of official bioethics advice in the governance of biotechnologies in the EU: the European Group on Ethics' Opinion on commercial cord blood banking. Science and Public Policy. 2012;39(1):105-17. CrossRef
Moll G, GeiÃŸler S, Catar R, et al. Cryopreserved or fresh mesenchymal stromal cells: only a matter of taste or key to unleash the full clinical potential of MSC therapy? Adv Exp Med Biol. 2016;951:77-98. CrossRef
Moroff G, Eichler H, Brand A, et al. Multiple-laboratory comparison of in vitro assays utilized to characterize hematopoietic cells in cord blood. Transfusion. 2006;46:507-15. CrossRef
Morris C, de Wreede L, Scholten M, et al. Chronic Malignancies and Lymphoma Working Parties of EBMT. Should the standard dimethyl sulfoxide concentration be reduced? Results of a European Group for Blood and Marrow Transplantation prospective noninterventional study on usage and side effects of dimethyl sulfoxide. Transfusion. 2014;54(10):2514-22. CrossRef
Motta JPR, Paraguassú-Braga FH, Bouzas LF, Porto LC. Evaluation of intracellular and extracellular trehalose as a cryoprotectant of stem cells obtained from umbilical cord blood. Cryobiology. 2014;68(3):343-8. CrossRef
Mueller C, Querol S. Chapter 7. Bone marrow registries and cord blood banks. In: Apperley J, Carreras E, Gluckman E, Masszi T, editors. Haematopoietic Stem Cell Transplantation. The EBMT Handbook 6th Edition. Genoa, Italy: Litoprint; 2012, p. 109-20.
Page KM, Mendizabal A, Betz-Stablein B, et al. Optimizing donor selection for public cord blood banking: Influence of maternal, infant, and collection characteristics on cord blood unit quality. Transfusion. 2014;54(2):340-52. CrossRef
Page KM, Zhang L, Mendizabal A, et al. Total colony-forming units are a strong, independent predictor of neutrophil and platelet engraftment after unrelated umbilical cord blood transplantation: a single-center analysis of 435 cord blood transplants. Biol Blood Marrow Transplant. 2011;17(9):1362-74. CrossRef
Page KM, Zhang L, Mendizabal A, et al. The Cord Blood Apgar: a novel scoring system to optimize selection of banked cord blood grafts for transplantation (CME). Transfusion. 2012;52(2):272-83. CrossRef
Pasha R, Elmoazzen H, Pineault N. Development and testing of a stepwise thaw and dilute protocol for cryopreserved umbilical cord blood units. Transfusion. 2017;57(7):1744-54. CrossRef
Passweg JR, Baldomero H, Bader P, et al. Hematopoietic stem cell transplantation in Europe 2014: more than 40 000 transplants annually. Bone Marrow Transplant. 2016;51(6):786-92. CrossRef
Passweg JR, Baldomero H, Basak GW, et al. European Society for Blood and Marrow Transplantation (EBMT). The EBMT activity survey report 2017: a focus on allogeneic HCT for nonmalignant indications and on the use of non-HCT cell therapies. Bone Marrow Transplant. 2019;54(10):1575-85. CrossRef
Patterson J, Moore CH, Palser E, et al. Detecting primitive hematopoietic stem cells in total nucleated and mononuclear cell fractions from umbilical cord blood segments and units. J Transl Med [Internet]. 2015 Mar 18 [cited 2019 Nov 19];13:94. Available from: https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-015-0434-z CrossRef
Perekhrestenko PM, Sivkovych SO, Hlukhenka HT, et al. [The use of cryopreserved cord blood in the treatment of patients with malignant lymphoma]. Likars'ka sprava. 2002;(2):76-80. Ukrainian.
Petersdorf EW. The World Marrow Donor Association: 20 years of international collaboration for the support of unrelated donor and cord blood hematopoietic cell transplantation. Bone Marrow Transplant. 2010;45(5):807-10. CrossRef
Petrini C. Ethical issues in umbilical cord blood banking: a comparative analysis of documents from national and international institutions. Transfusion. 2013;53(4):902-10. CrossRef
Ponce DM, Hilden P, Devlin SM, et al. High disease-free survival with enhanced protection against relapse after double-unit cord blood transplantation when compared with T cell-depleted unrelated donor transplantation in patients with acute leukemia and chronic myelogenous leukemia. Biol Blood Marrow Transplant. 2015;21:1985-93. CrossRef
Popat U, Mehta RS, Rezvani K, et al. Enforced fucosylation of cord blood hematopoietic cells accelerates neutrophil and platelet engraftment after transplantation. Blood. 2015;125(19):2885-92. CrossRef
Powell K, Kwee E, Nutter B, et al. Variability in subjective review of umbilical cord blood colony forming unit assay. Cytometry B Clin Cytom. 2016;90(6):517-24. CrossRef
Pushkar NS, Belous AM, Tsutsaeva AA, et al. [Low-temperature preservation of the bone marrow]. Kyiv: Naukova Dumka; 1976. 288 p. Russian.
Quality of cord blood unit [Internet]. WMDA; 2019 [updated 2019 Dec 9]; [cited 2019 Dec 9]. Available from: https://statistics.wmda.info/
Reich-Slotky R, Colovai AI, Semidei-Pomales M, et al. Determining post-thaw CD34+ cell dose of cryopreserved haematopoietic progenitor cells demonstrates high recovery and confirms their integrity. Vox Sang. 2008;94(4):351-7. CrossRef
Rich IN. Improving quality and potency testing for umbilical cord blood: a new perspective. Stem Cells Transl Med. 2015;4(9):967-73. CrossRef
Rocha V, Labopin M, Ruggeri A, et al. Unrelated cord blood transplantation: outcomes after single-unit intrabone injection compared with double-unit intravenous injection in patients with hematological malignancies. Transplantation. 2013;95(10):1284-91. CrossRef
Rocha V, Labopin M, Sanz G, et al. Acute Leukemia Working Party of European Blood and Marrow Transplant Group; Eurocord-Netcord Registry. Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia. N Engl J Med. 2004;351(22):2276-85. CrossRef
Rodrigues CA, Rocha V, Dreger P, et al. Eurocord-Netcord and the Lymphoma Working Party; Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation. Alternative donor hematopoietic stem cell transplantation for mature lymphoid malignancies after reduced-intensity conditioning regimen: similar outcomes with UCB and unrelated donor peripheral blood. Haematologica. 2014;99(2):370-7. CrossRef
Romanova AF. [Chapter 5. Allogeneic bone marrow transplantation in complex treatment of patients with hypo- and aplastic anemia] . In: Romanova AF. [Hypoplastic and aplastic anemia]. Kyiv: Zdorovia; 1982. p. 78-122. Russian.
Roy S, Arora S, Kumari P, Ta M. A simple and serum-free protocol for cryopreservation of human umbilical cord as source of Wharton's jelly mesenchymal stem cells. Cryobiology. 2014;68(3):467-72. CrossRef
Rubinstein P, Dobrila L, Rosenfield RE, et al. Processing and cryopreservation of placental/umbilical cord blood for unrelated bone marrow reconstitution. Proc Natl Acad Sci USA. Medical Sciences. 1995;92:10119-22. CrossRef
Ruggeri A, Rocha V, Masson E, et al. Impact of donor specific anti-HLA antibodies on graft failure and survival after reduced intensity conditioning-unrelated cord blood transplantation: a Eurocord, Société Francophone d’Histocompatibilité et d’Immunogénétique (SFHI) and Société Française de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC) analysis. Haematologica. 2013;98(7):1154-60. CrossRef
Sacchi N. Is it time to re-think a sustainable banking model for the Italian Cord Blood Network? Blood Transfus. 2018;16(3):221-3. CrossRef
Sandhu KS, Brunstein C, DeFor T, et al. Umbilical cord blood transplantation outcomes in acute myelogenous leukemia/myelodysplastic syndrome patients aged ≥70 years. Biol Blood Marrow Transplant. 2016;22(2):390-3. CrossRef
Secco M, Zucconi E, Vieira NM, et al. Multipotent stem cells from umbilical cord: cord is richer than blood! Stem Cells. 2008;26(1):146-50. CrossRef
Shrago MI. [Chapter 2. Cryoprotectants]. In: Tsutsayeva AA, editor. [Cryopreservation of cell suspensions]. Kyiv: Naukova Dumka; 1983. p. 12-25. Russian.
Shu Z, Heimfeld S, Gao D. Hematopoietic SCT with cryopreserved grafts: adverse reactions after transplantation and cryoprotectant removal before infusion. Bone Marrow Transplant. 2014;49(4):469-76. CrossRef
Snowden JA, McGrath E, Duarte RF, et al. JACIE accreditation for blood and marrow transplantation: past, present and future directions of an international model for healthcare quality improvement. Bone Marrow Transplant. 2017;52(10):1367-71. CrossRef
Solocinski J, Osgood Q, Wang M, et al. Effect of trehalose as an additive to dimethyl sulfoxide solutions on ice formation, cellular viability, and metabolism. Cryobiology. 2017;75:134-43. CrossRef
Son JH, Heo YJ, Park MY, et al. Optimization of cryopreservation condition for hematopoietic stem cells from umbilical cord blood. Cryobiology. 2010;60(3):287-92. CrossRef
Standards & Accreditation. AABB Accredited Cord Blood (CB) Fasilities [Internet]. AABB; 2019 [cited 2019 Nov 5]. Available from: http://www.aabb.org/sa/facilities/celltherapy/Pages/CordBloodAccrFac.aspx
Stewart CL, Aparicio LC, Kerridge IH. Ethical and legal issues raised by cord blood banking - the challenges of the new bioeconomy. Med J Aust. 2013;199(4):290-2. CrossRef
Stolzing A, Naaldijk Y, Fedorova V, Sethe S. Hydroxyethylstarch in cryopreservation - mechanisms, benefits and problems. Transfus Apher Sci. 2012;46(2):137-47. CrossRef
Sum AK, Faller R, de Pablo JJ. Molecular simulation study of phospholipid bilayers and insights of the interactions with disaccharides. Biophys J. 2003;85(5):2830-44. CrossRef
Syme R, Bewick M, Steward D, et al. The role of depletion of dimethyl sulfoxide before autografting: on hematologic recovery, side effects, and toxicity. Biol Blood Marrow Transplant. 2004;10(2):135-41. CrossRef
Tanhehco YC, Schwartz J, Linenberger ML. Defining the quality of hematopoietic stem cell products: the devil is in the details. Transfusion. 2015;55(10):2300-3. CrossRef
The Guide to the quality and safety of tissues and cells for human application. EDQM 4th Edition [Internet]. EDQM Coucil of Europe; 2019 [cited 2019 Dec 16]. Available from: https://www.edqm.eu/en/organs-tissues-and-cells-technical-guides
Total Number of Donors and Cord blood units [Internet]. WMDA; 2019 [updated 2019 Dec 9]; [cited 2019 Dec 9]. Available from: https://statistics.wmda.info/
Tsutsayeva AA, Tsyganenko AYa, Zheltyakova IA, et al. Influence of hypothermic storage before and after cryopreservation on properties of nucleated components and whole human cord blood plasma. Problems of Cryobiology. 2006;16(1):45-55. Full Text
Ustun C, Giannotti F, Zhang MJ, et al. Outcomes of UCB transplantation are comparable in FLT3+ AML: results of CIBMTR, EUROCORD and EBMT collaborative analysis. Leukemia. 2017;31(6):1408-14. CrossRef
van den Broek BTA, Page K, Paviglianiti A, et al. Early and late outcomes after cord blood transplantation for pediatric patients with inherited leukodystrophies. Blood Adv. 2018;2(1):49-60. CrossRef
Vieira Paladino F, de Moraes Rodrigues J, da Silva A, Goldberg AC. The Immunomodulatory Potential of Wharton's Jelly Mesenchymal Stem/Stromal Cells. Stem Cells Int [Internet]. 2019 Jun 11 [cited 2019 Dec 12];2019:3548917. Available from: https://www.hindawi.com/journals/sci/2019/3548917/ CrossRef
Volarevic V, Markovic BS, Gazdic M, et al. Ethical and Safety Issues of Stem Cell-Based Therapy. Int J Med Sci [Internet]. 2018 Jan 1 [cited 2019 Dec 12];15(1):36-45. Available from: https://www.medsci.org/v15p0036.htm CrossRef
Wagner JE, Gluckman E. Umbilical cord blood transplantation: the first 20 years. Semin Hematol. 2010;47(1):3-12. CrossRef
Whitby A, Whitby L, Fletcher M, et al. ISHAGE protocol: are we doing it correctly? Cytometry B Clin Cytom. 2012;82(1):9-17. CrossRef
WMDA: matching donors, serving patients [Internet]. WMDA; 2019 [updated 2019 Dec]; [cited 2019 Dec 16]. Available from: https://wmda.info
World Marrow Donor Association International Standards for Unrelated Hematopoietic Progenitor Cell Donor Registries. WMDA Standards 2017. Effective from 1st January 2017 [cited 2018 Jen 10]; 23 p. Available from: https://wmda.info/wp-content/uploads/2017/05/20170101-BCST-WMDA-Standards-2017.pdf.
Yuan Y, Yang Y, Tian Y, et al. Efficient long-term cryopreservation of pluripotent stem cells at -80 Â°C. Sci Rep [Internet]. 2016 Oct 3 [cited 2017 Dec 20]; 2016 ( 6): Article number: 34476 . Available from: https://www.nature.com/articles/srep34476 CrossRef
Zhou X, Liu Z, Shu Z, et al. A dilution-filtration system for removing cryoprotective agents. ASME.ORG: J Biomech Eng [Internet]. 2011 Jen 31 [cited 2018 Feb 10];133(2): Article ID 021007. Available from: http://biomechanical.asmedigitalcollection.asme.org/article.aspx?articleid=1421143 CrossRef
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