Effect of Amphiphiles on Hypertonic Hemolysis of Erythrocytes, Modified with Temperature of 49Â°C
Keywords:hypertonic stress, erythrocytes, spectrin, amphiphilic compounds
The effect of thermal pre-treatment of human and bovine erythrocytes on their sensitivity to hypertonic stress (4.0 mol/l NaCl) at 37 and0Â°Cwas studied. It has been shown that cell incubation at49Â°C, causing spectrin denaturation, decreases the level of human erythrocyte hypertonic damage and does not affect the integrity of bovine erythrocytes at37Â°C. Hypertonic hemolysis of modified mammalian erythrocytes does not change at0Â°C. Cytoskeletal spectrin denaturation of bovine and human erythrocytes results in reduction of antihemolytic activity of amphiphilic substances (sodium decyl sulfate, dodecyl-Î²,D-maltoside, trifluoroperazine) at 37 and0Â°C.
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Copyright (c) 2020 N. A. Pisarenko, N. M. Shpakova
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