Determination of Immunity T-cell Link State and Content of Cancer Stem Cells as Criterion to Estimate Efficiency of Preventive Breast Cancer Therapy with Cryopreserved Fetal Liver Cells
Keywords:cryopreservation, fetal liver, bone marrow cells, hematopoietic stem cells
The expediency to use cryopreserved fetal liver cells (cFLCs) for preventive treatment of breast cancer (BC) is proved by a wide range of produced by them biologically active substances with immunomodulatory and antineoplastic activity. Revealing cancer stem cells (CSCs) in the mammary gland (MG) and determination of the immune system (IS) status are the methods of early diagnosis and evaluation of preventive treatment efficiency of breast cancer. The experiments were performed in 16-month-old C3H/He mice which in 6 months were injected by cryopreserved or native FLCs of 14 gestation days at a dose of 1Ã—106 or 5Ã—106 cells.
Probl Cryobiol Cryomed 2014; 24(3):238-248.
Aldahmash A., Atteya M., Elsafadi M. et al. Teratoma formation in immunocompetent mice after syngeneic and allogeneic implantation of germline capable mouse embryonic stem cells. Asian Pac. J Cancer Prev 2013; 14(10): 5705â€“5711.
Bendyug G.D., Smykodub O.I., Grynevych Yu.A. et al. Effect of fetal liver cells' transplantation on some indices characterizing immune system of cancer patients in dynamic of anticancer treatment. Gematologiya i perelyvannya krovi 1998 (8): 214â€“220.
Berry M.N., Friend D.S. High yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. J Cell Biol 1969; 43(3): 506â€“520. CrossRef
Bhattacharya N., Mukherjee K.L., Chettri M.K. et al. Unique experience with human pre-immune (12 weeks) and hypo-immune (16 weeks) fetal thymus transplant in a vascular subcutaneous axillary fold in patients with advanced cancer: a report of two cases. Eur J Gynaecol Oncol 2001; 22(4): 273â€“277.
Bilyns'kyi B.T., Volod'ko N.A., Shparykh Ya.V. Immunological mechanisms of natural antitumor resistance. Kyiv: Naukova Dumka; 1991.
Bilyns'kyi B.T., Lohins'kyi V.O., Savchyk O.B., Oshchebs'kyi O.T. The use of cryopreserved hemopoietic cells of the human embryonic liver in stable depressions of hematopoiesis in cancer patients. Lik Sprava; 1996. (10â€“12): 77â€“79.
Bondarovich N.A., Ostankov M.V., Sirous M.A. et al. State of immune system of mice with genetically determined development of breast cancer after application of cryopreserved fetal liver cells. Visnyk of V.N. Karazin Kharkiv National University. Series: Biology 2006; 4(748): 110â€“120.
Bondarovich N.A., Safranchuk O.V., Ostankov M.V., Sirous M.A. Correction of the immune system using fetal liver cells in breast cancer development. AktualnÑ– Pytannya Farmatsevtychnoi ta Medychnoi Nauky ta Praktyky 2009; 2(22): 23â€“26.
Chang W.W., Lin R.J., Yu J. et al. The expression and significance of insulin-like growth factor-1 receptor and its pathway on breast cancer stem/progenitors. Breast Cancer Res 2013; 15(3): R39.
Chekhun V.F. Antitumor vaccines. Onkologiya 2008; 10(2): 204â€“205.
Dong W., Qiu C., Shen H. et al. Antitumor effect of embryonic stem cells in a non-small cell lung cancer model: antitumor factors and immune responses. Int J Med Sci 2013; 10(10): 1314â€“1320. CrossRef PubMed
Frimel G. Immunological methods. Moscow: Meditsina; 1987: 472 p.
Giraudi P.J., Almada L.L., Mamprin M.E. et al. The assessment of viability in isolated rat hepatocytes subjected to cold or subzero non-freezing preservation protocols using a propidium iodide modified test. Cryo Letters 2005; 26(3): 169â€“184.
Goltsev A.N. Bondarovich N.A., Safranchuk O.V., Ostankov M.V. Modifying effect of cryopreservation on anti-tumor activity of FLCs: Proceedings of the conference 'Application of cryopreservation from human tissue engineering to plant genebank integration'; 2009 Sep 7â€“9; Hanover; 2009. p. 39.
Goltsev A.N., Dubrava T.G., Lutsenko E.D. et al. Manifestation of immune correcting effect of cryopreserved cells of fetal liver of different gestation terms under development conditions of experimental model of graft versus host reaction. Kletoch-naya Transplantologia i Tkanevaya Inzheneriya 2010; 5(3): 82â€“86.
Goltsev A.N., Popova K.N., Sirous M.A. Cryopreservation as optimizing factor in therapeutic effect of products of embryo-fetoplacental complex (PEFPC) Part II. Fetal liver cell correction of lymphohemopoietic complex state in experimental animals with AIHA. Problems of Cryobiology 2006; 16(4): 396â€“407.
Goltsev A.N., Safranchuk O.V., Bondarovich N.A., Ostankov M.V. Change in cryolability of cancer stem cells during in vivo culture of Ehrlich adenocarcinoma. Fiziol Zh 2011; 57(4): 68â€“76.
Gonzburg W.H., Salmons B. Factors controlling the expression of mouse mammary tumour virus. Biochem J 1992; 283: 625â€“632. CrossRef
Gordeeva O.F., Nikonova T.M. Development of experimental tumors formed by mouse and human embryonic stem and teratocarcinoma cells after subcutaneous and intraperitoneal transplantations into immunodeficient and immunocompetent mice. Cell Transplant 2013; 22(10): 1901â€“1914. CrossRef PubMed
Grinevich Yu.A., Khranovskaya N.N., Bendyug G.D. The in-fluence of embryonic liver cells on natural anti-tumor organism resistence. Immunologiya 2003; (3): 153â€“157.
Huang J., Li C., Wang Y. et al. Cytokine-induced killer (CIK) cells bound with anti-CD3/anti-CD133 bispecific antibodies target CD133 (high) cancer stem cells in vitro and in vivo. Clin Immunol 2013; 149(1): 156â€“168. CrossRef PubMed
Kuo Y.C., Su C.H., Liu C.Y. et al. Transforming growth factor-beta induces CD44 cleavage that promotes migration of MDA-MB-435s cells through the up-regulation of membrane type 1-matrix metalloproteinase. Int J Cancer 2009; 124(11): 2568â€“2576. CrossRef PubMed
Lal A., Chan L., Devries S. et al. FOXP3-positive regulatory T lymphocytes and epithelial FOXP3 expression in synchronous normal, ductal carcinoma in situ, and invasive cancer of the breast. Breast Cancer Res Treat 2013; 139(2): 381â€“390. CrossRef PubMed
Monaghan M., Mulligan K.A., Gillespie H. et al. Epidermal growth factor up-regulates CD44-dependent astrocytoma invasion in vitro. J Pathol 2000; 192(4): 519â€“525. CrossRef
Ostankov M.V., Goltsev A.N., Dubrava T.G. et al. Application of cryopreserved fetal liver cells for correction of immune status of recipients with GVHD in experiment. Medytsyna Syogodni i Zavtra 2011; (1â€“2): 50â€“51.
Radziyevska L.V. Improving of life quality of pancreatic cancer patient by transplantation of embryonic liver cells. Transplantologiya 2003; 4(1): 181â€“183.
Tarutinov V.I. Questions and prospects of hormone therapy of breast cancer patients. Onkologiya 2005; 7(2): 1â€“4.
Tashiev R.K., Barateli V.T. Treatment of breast cancer in condition of specialized oncological medical departments and general health care network. Khir Ukrain 2010; (3): 78â€“81.
Yampolskaya Ye.Ye., Goltsev A.N. Modulation of state of monocyte-phagocyte system cells in animals with autoimmune pathology by fetal liver cells. Patologiya 2011; 8(2): 105â€“107.
Yampolskaya Ye.Ye., Kravchenko M.A., Dubrava T.G., Goltsev A.N. Influence of cryopreserved fetal liver cells on immunoinflammatory process activity in rheumatic arthritis animals. Bulletin of V.N. Karazin Kharkiv National University. Series: Biology 2012; 15(1008): 177â€“186.
Zeilstra J., Joosten S.P.J., Dokter M. et al. Deletion of the WNT target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis. Cancer Res 2008; 68(10): 3655â€“3661. CrossRef PubMed
Zozulya Yu.I., Lisyanyy M.I., Oliynik G.M. Determination of antitumor activity of embryonic brain cells. Onkologiya; 5(2): 126â€“127.
How to Cite
Copyright (c) 2020 Anatoliy N. Goltsev, Nikolay A. Bondarovich, Andrey V. Kuznyakov, Maksim V. Ostankov, Lyudmila V. Ostankova, Olga V. Chelombit'ko
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).