Stipulation of the Possibility to Use Embryonic Neuronal Cells when Treating Organospecific Autoimmune Diseases

Authors

  • A. N. Goltsev
  • N. N. Babenko

Keywords:

, transplantation of embryonic neuronal cells, cryopreservation, allergic encephalomyelitis

Abstract

There was studied the possibility of this pathology treatment with intraperitoneal introduction of native and cryopreserved embryonic neuronal cells (ENCs) in the model of allergic encephalomyelitis as experimental analogue of multiple sclerosis (MS). The efficiency of performed therapy is established to be determined both by morphofunctional status of transplants and their introduction terms, i.e. to the 7th and 14th day of the pathological process development. It has been noted that cryopreserved ENCs (cENCs) in contrast to native ENCs (nENCs) during the introduction had correction peculiarities of clinical and neurological status of animals, immune regulatory index, killer activity of splenocytes and content of finely dispersed circulating immune complexes (fCIC) in blood serum.

Author Biographies

A. N. Goltsev

Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv

 

N. N. Babenko

Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkiv

 

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Published

2006-06-25

How to Cite

Goltsev, A. N., & Babenko, N. N. (2006). Stipulation of the Possibility to Use Embryonic Neuronal Cells when Treating Organospecific Autoimmune Diseases. Problems of Cryobiology and Cryomedicine, (2), 49–61. Retrieved from https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/1030

Issue

Section

Theoretical and Experimental Cryobiology