Impact of Various Regimens of Rhythmic Extreme Cold Exposures on Hormone and Lipid Content in Blood Serum of Young and Aged Rats
DOI:
https://doi.org/10.15407/cryo29.03.206Keywords:
rhythmic extreme cold influence, thyroxine, triiodothyronine, dehydroepiandrosterone, corticosterone, testosterone, estradiol, lipid profileAbstract
At present, there is a close relationship between age-related changes in the endocrine system, metabolic disorders and the development of diseases of internal organs, characteristic of the elderly. Rhythmic extreme cold influence (RECI) (–120°C) are a powerful physiotherapeutic procedure that activates the body's adaptive reserves. However, in opposition the high therapeutic efficacy of the RECI, in some cases the use of extreme cooling, especially in the elderly, is accompanied by the occurrence of side effects. Therefore, the effect of different modes of RECI on the content of hormones and lipids in the blood serum of young and old rats was studied. It has been established that in the young and old animals the use of RECI in temperature regimes (–120°C; –120°C; –120° C) and (–60°C; –120°C; –120°C) led to stable stimulation of the thyroid, adrenal and reproductive system in comparison with the (–60°C; –60°C; –60°C). At the same time, the regime (–60°C; –120°C; –120°C) had a "milder" effect on the lipid profile of the blood serum of young and old rats, since it was not accompanied by a pronounced stress reaction of the organism in the form of hyperlipidemia.
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Probl Cryobiol Cryomed 2019; 29(3): 206–220.
References
Anisimov VN. [Experimental research on ageing in Russia]. Experimental Gerontology. 2001; 36(7): 935-45. Russian. CrossRef
Atramentova LA, Utevskaya OM. [Statistical methods in biology]. Gorlovka.: Likhtar; 2008. 248 p. Russian.
Babijchuk VG. Ðge peculiarities of nitrogen oxide role in adaptation mechanisms of animals to rhythmic cold effects. Report 1. Сontent of final products of no exchange in blood and myocardium of young and aged animals after rhythmic cold effects. Problems of Cryobiology. 2006; 16(4): 377-89.
Babijchuk VG, Kozlov OV. [Effect of extreme cooling on indices of vegetative regulation of cardiac rhythm in rats of different age groups]. Problems of Cryobiology. 2008; (3): 374-78.
Babijchuk VG. Influence of extreme cryotherapy on the morphofunctional state of the central nervous and cardiovascular systems. Problems of Cryobiology. 2005; 15(3): 458-64.
Babijchuk VG. [Ðge peculiarities of nitrogen oxide role in adaptation mechanisms of animals to rhythmic cold effects. Report 2. Сontent of final products of no exchange in cortex and hypothalamus of young and aged animals after rhythmic cold effects]. Problems of Cryobiology. 2007; 17(1): 25-37.
Babijchuk VG. [Peroxide oxidation of lipids in extreme cooling of rats]. Ukr Biochem J. 2007; 79(1): 112-23. Russian.
Babijchuk VG, Marchenko VS. [Structural and functional state of the blood-brain barrier of the hypothalamus of old rats under the action of extreme cooling]. World of Medicine and Biology. 2005; (3): 91-4. Russian.
Babijchuk VG, Marchenko VS, Babijchuk GA. Structural and functional effect mechanisms of extreme cooling on hypothalamus thermoregulatory centers. Problems of Cryobiology. 2004; (2): 62-70.
Babiychuk GA, Kozlov OV, Lomakin II, inventors; Institute for Problems of Cryobiology and Cryomedicine, assignee. [Cryocameras for experimental cooling of laboratory animals]. Patent of Ukraine â„– 40168. 25.03.2009. Ukrainian.
Babiychuk LV, Sirotenko LA, Malova NG. [Lipid and glucose levels in the rats blood serum under the stress-induced hypertension and after the administration of cryopreserved cord blood]. Problems of Endocrine Pathology. 2014; (3): 89-96. Russian. CrossRef
Babiychuk VG, Marchenko VS, Marchenko LM. [Structural functional state of the blood-brain barrier with rhythmic action of positive (+12оC) and extremely low (-120оC) temperatures]. Neuroscience: Theoretical and Clinical Aspects. 2008; 4(1): 68-74. Ukrainian.
Chazova IE. [Treatment of dyslipidemia in patients with arterial hypertension]. Terapevtichesky Arkih. 2007; 79(4): 53-7. Russian.
Feldman HA, Longcope C, Derby CA, et al. Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study. J Clin Endocr Metab. 2002; 87(2): 589-98. CrossRef
Friedewald W, Levy R, Fredrickson D. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin Chem. 1972; 18(6): 499-502.
Glantz S. [Primer of biostatistics]. Moscow: Praktika; 1998. 459 p. Russian.
Martynova YuV, Babiychuk VG, Sirotenko LA. [Thyroid hormone levels in the blood serum of rats on the background of rhythmic extreme cooling]. Materials of the II International Scientific and Practical Teleconference 'Advances in Science and Technology'; 2015 Dec 25; Penza, Russia. Penza; 2015. р. 10-11. Russian.
Nepomnyashchikh LM. [Medico-biological aspects of adaptation processes]. Novosibirsk: Nauka; 1975. 376 p. Russian.
Reaven GM. Insulin resistance/compensatory hyperinsulinemia, essential hypertension, and cardiovascular disease. J Clin Endocrin. 2003; 88(6): 2399-403. CrossRef
Sans S, Kesteloor H, Kromhout D, et al. The burden of cardiovascular diseases mortality in Europe. Task Force of the European Society of Cardiology on Cardiovascular Mortality and Morbidity Statistics in Europe. Eur Heart J. 1997; 18(8): 1231-248. CrossRef
Shilov AM, Chubarov MV, Melnik MV. [Arterial hypertension and metabolic syndrome]. International Medical Journal. 2002; 11(21): 1145-149. Russian.
Skulachev VP. [Energy accumulation in the cell]. Moscow: Nauka; 1969. 440 р. Russian.
Soloviev RM, Kozlovsky VYu, Leontiev AA. [Age dynamics of thyroid hormones in the blood of repair heifers of the golshtshina breed]. Izvestia Orenburgskogo Gosudarstvennogo Agrarnogo Universiteta. 2011; 32(4): 301-3. Russian.
Verin VK, Ivanov VV. [Hormones and their effects]. St. Petersburg: Foliant; 2011. 136 p. Russian.
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