Chymase, Tonin and Calpains under Artificial Hypometabolic State in Hamsters

Authors

  • L. M. Samokhina Institute of Therapy named by L.T. Malaya of the Academy of Medical Sciences of Ukraine, Kharkov
  • V. V. Lomako Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • A. V. Shilo Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Keywords:

chymase, tonin, calpains, hypometabolic state, hamsters

Abstract

The activity of enzymes of alternative ways of angiotensin II formation (chymase, tonin) and calcium-dependent proteinases (calpains) in hamsters serum, nuclear-free fractions of tissue gomogenates of cerebral cortex, brain stem, hypothalamus, cerebellum, lung, heart, liver and kidneys under artificial hypometabolic state (AHMS) (Andjus-Bakhmetev-Giaja method) with enzymatic (10–9–10–10 g) method have been studied. It has been shown that lung, heart, liver, kidneys and brain structures, which are critical for vital function were the most susceptible to AHMS development and at the self-rewarming stage. Increased chymase activity in liver and kidneys on the background of decreased tonin activity and elevated calpains activity may indicate vasoconstriction development and stimulation of cell and tissue damage, correspondingly. All the changes found were mainly normalized after 24 h.

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Published

2007-12-15

How to Cite

Samokhina, L. M., Lomako, V. V., & Shilo, A. V. (2007). Chymase, Tonin and Calpains under Artificial Hypometabolic State in Hamsters. Problems of Cryobiology and Cryomedicine, 17(4), 347–355. Retrieved from https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/481

Issue

Vol. 17 No. 4 (2007): Problems of Cryobiology

Section

Theoretical and Experimental Cryobiology

License

Copyright (c) 2020 L. M. Samokhina, V. V. Lomako, A. V. Shilo

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