Experimental Substantiation for Applying Cryopreserved Preparations of Embryofetoplacental Complex to Correct Thyroid Gland Pathologies Report 2. The Effect of Human Fetal Cell Suspension Biopreparation on Functional Activity of Rabbit Thyroid Gland

Authors

  • N. G. Malova V.Ya. Danilevsky Institute for Problems of Endocrine Pathology of Academy of Medical Sciences of Ukraine, Kharkov
  • T. N. Yurchenko Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • T. S. Bozhko V.Ya. Danilevsky Institute for Problems of Endocrine Pathology of Academy of Medical Sciences of Ukraine, Kharkov
  • I. V. Komarova V.Ya. Danilevsky Institute for Problems of Endocrine Pathology of Academy of Medical Sciences of Ukraine, Kharkov
  • D. V. Strona State Enterprise "Interdepartmental Scientific Center of Cryobiology and Cryomedicine of National Academy of Sciences, Academy of Medical Sciences and Ministry of Health Care of Ukraine", Kharkov
  • Yu. M. Solonets V.Ya. Danilevsky Institute for Problems of Endocrine Pathology of Academy of Medical Sciences of Ukraine, Kharkov
  • V. I. Chujkova Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Keywords:

hypothyrosis, fetal tissues, hormonogenesis, xenotransplantation

Abstract

The xenotransplantation effect of cryopreserved biopreparation of human fetal tissue suspension (FTS) on thyroid gland (TG) functional activity in rabbits with a suppressed thyroid function (an experimental mercazolil hypothyrosis) was investigated. A normalising effect of the therapy performed on the experimental animals’ thyroid system was noted. The FTS stimulating effect and its maximum were observed by the second week and second month after introduction, correspondingly. The hormonogenesis stimulation in TG was established as realising under a direct FTS influence on thyroid parenchyma with no central regulation mechanism participation; a dominating effect of preparation on thyroxin biosynthesis with no significant change in T3 level.

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Published

2007-12-15

How to Cite

Malova, N. G., Yurchenko, T. N., Bozhko, T. S., Komarova, I. V., Strona, D. V., Solonets, Y. M., & Chujkova, V. I. (2007). Experimental Substantiation for Applying Cryopreserved Preparations of Embryofetoplacental Complex to Correct Thyroid Gland Pathologies Report 2. The Effect of Human Fetal Cell Suspension Biopreparation on Functional Activity of Rabbit Thyroid Gland. Problems of Cryobiology and Cryomedicine, 17(4), 403–409. Retrieved from https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/487

Issue

Vol. 17 No. 4 (2007): Problems of Cryobiology

Section

Cryomedicine, Clinical and Experimental Transplantology

License

Copyright (c) 2020 N. G. Malova, T. N. Yurchenko, T. S. Bozhko, I. V. Komarova, D. V. Strona, Yu. M. Solonets, V. I. Chujkova

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