Correction of Anemia Resulting From 5-Fluorouracil Toxic Effect Using Cryopreserved Preparations of Cord Blood

Authors

  • Olga V. Kudokotseva Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • Igor F. Kovalenko Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • Ivan I. Lomakin Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • Georgiy A. Babijchuk Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

DOI:

https://doi.org/10.15407/cryo24.04.312

Keywords:

cord blood, chemotherapy, anemia, erythrocytes, sphericity index, hemolysis

Abstract

The use of the most chemotherapeutic drugs leads to the development of hypoplasia of bone marrow hematopoiesis and severe anemia. The effect of cryopreserved preparations of human cord blood (HCB) (cellular and acellular ones) on the reco-very of erythroid elements in peripheral blood (PB) was studied in the model of cytostatic hemodepression with 5-fluorouracil (5-FU) in mice. An intravenous administration of cryopreserved nucleated cells (cNCs) of HCB was shown as contributed to an accelerated recovery of the absolute number of erythrocytes at the earlier terms than in the groups of comparison (5-FU and 5-FU + cell-free HCB supernatant). There was established, that to day 9 after administering HCB cNCs the erythrocyte number in murine PC was completely recovered and their outer contour was kept.


Probl Cryobiol Cryomed 2014; 24(4):312-321.

Author Biographies

Olga V. Kudokotseva, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Department of Cryophysiology

Igor F. Kovalenko, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Department of Cryophysiology

Ivan I. Lomakin, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Department of Cryophysiology

Georgiy A. Babijchuk, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov

Department of Cryophysiology

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Published

2014-12-20

How to Cite

Kudokotseva, O. V., Kovalenko, I. F., Lomakin, I. I., & Babijchuk, G. A. (2014). Correction of Anemia Resulting From 5-Fluorouracil Toxic Effect Using Cryopreserved Preparations of Cord Blood. Problems of Cryobiology and Cryomedicine, 24(4), 312–321. https://doi.org/10.15407/cryo24.04.312

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Section

Cryomedicine, Clinical and Experimental Transplantology