Effect of Different Cryopreservation Regimens on Bone Marrow Hemopoietic Stem Cell Integrity in Animals With Autoimmune Diseases Part 2. In vivo Estimation of Functional Status of Cryopreserved Bone Marrow Hemopoietic Progenitors

Authors

  • A. N. Goltsev Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • T. G. Dubrava Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • A. Yu. Kozlova Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • M. V. Ostankov Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • T. M. Gurina Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkov
  • A. M. Kurov Institute of Medical Radiology named after S.P. Grigoryev of the Academy of Medical Sciences of Ukraine, Kharkov

Keywords:

bone marrow, hemopoietic progenitors (GM-CFU, CFUs), autoimmune diseases, adjuvant arthritis, cryopreservation

Abstract

Functional characteristics of bone marrow hemopoietic stem cells of healthy animals and with autoimmune diseases before and after cryopreservation with different regimens have been comparatively determined in vivo. The principle differences between an initial functional status of hemopoietic precursors of healthy donors and with autoimmune diseases, as well as its changes under similar cryopreservation conditions have been demonstrated. The “optimum†of CFUs colony-forming activity of healthy animals and those with adjuvant arthritis was noted as realised under bone marrow cryopreservation with different regimens.

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Published

2007-06-15

How to Cite

Goltsev, A. N., Dubrava, T. G., Kozlova, A. Y., Ostankov, M. V., Gurina, T. M., & Kurov, A. M. (2007). Effect of Different Cryopreservation Regimens on Bone Marrow Hemopoietic Stem Cell Integrity in Animals With Autoimmune Diseases Part 2. In vivo Estimation of Functional Status of Cryopreserved Bone Marrow Hemopoietic Progenitors. Problems of Cryobiology and Cryomedicine, 17(2), 126–140. Retrieved from https://cryo.org.ua/journal/index.php/probl-cryobiol-cryomed/article/view/512

Issue

Vol. 17 No. 2 (2007): Problems of Cryobiology

Section

Theoretical and Experimental Cryobiology

License

Copyright (c) 2020 A. N. Goltsev, T. G. Dubrava, A. Yu. Kozlova, M. V. Ostankov, T. M. Gurina, A. M. Kurov

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