Сучасні підходи і перспективи методів ліофілізації ядерних клітин кордової крові людини
DOI:
https://doi.org/10.15407/cryo33.04.227Ключові слова:
лейкоконцентрат кордової крові людини, ліофілізація, ліопротектори, антиоксидантиАнотація
В огляді узагальнено дані щодо перспектив застосування ліофілізації як методичного підходу до збереження структурно-функціональних характеристик з метою довгострокового зберігання лейкоконцентрату кордової крові людини (ЛККЛ). Показано переваги методу ліофілізації порівняно з низькотемпературним зберіганням, природнім або тепловим висушуванням. Розглянуто питання впливу фізико-хімічних факторів, які реалізуються на етапі ліофілізації, на структурно-функціональні характеристики клітин ЛККЛ. Обговорюється важливість таких чинників, як-от концентрація клітин, умови зберігання, залишкова вологість у забезпеченні збереження ліофілізованого матеріалу. У роботі проаналізовано дані щодо використання ліопротекторів та антиоксидантів в умовах ліофілізації та обговорюються питання безпеки використання методів доставлення ліопротекторів відносно геномного профілю клітин.
Probl Cryobiol Cryomed 2023; 33(4): 227–249
Посилання
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