Implantation of Cryopreserved Human Placental Fragments Restores Prooxidant-Antioxidant Balance in Experimental Animals of Late Ontogeny
DOI:
https://doi.org/10.15407/cryo27.01.061Keywords:
cryopreserved bioobjects of placental origin, pro-and antioxidant system, aging, geriatricsAbstract
The studies have shown that animals of late ontogeny had the misbalance in prooxidative-antioxidative system of blood serum, liver and gonads with shift to the proxidant activity. Nevertheless, the implantation of cryopreserved human placenta fragments to experimental animals increased the activity of endogenous antioxidant system and contributed to the correction of pathological changes associated with aging. Analysis of the findings indicated that the restoration processes occurred both at cell and organism levels. The use of cryopreserved placental fragments in pre-senile age led to a gradual diverse correction of senile involutions, and an increased activity of endogenous antioxidant system during their sanogenesis substantiated the perspective of preventive and therapeutic protocols to treat geriatric pathologies.
Probl Cryobiol Cryomed 2017; 27(1): 61–70
References
Anisimov V.N. Molecular and physiological mechanisms of aging: 2nd edition, revised and enlarged. Saint-Petersburg. Nauka; 2008.
Asakawa T., Matsushita S. Coloring condition of thiobarbituric acid test for detecting lipid hydroperoxides. Lipids 1980; 15(3): 137–140. CrossRef
Farhat M.Y., Lavigne M.C., Ramwell P.W. The vascular protective effects of estrogen. FASEB J 1996; 10 (5): 615–624. PubMed
Jonathan R.C., Saltzman B.M., Yanke A.B., Cole B.J. Derived products in sports medicine: basic science, early results, and potential clinical applications. Am J Sports Med 2016; 44(9): 2425–2434. CrossRef PubMed
Klebanov G.I., Babenkova I.V., Teselkin Yu.O. et al. Assessment of antioxidant activity of blood plasma. Laboratornoye Delo 1988; (5): 59–62.
Kumara S., Lombardb D.B. Finding Ponce de Leon's pill: challenges in screening for anti-aging molecules. F1000Rev 2016; 06.
Lankin V.Z., Gurevich S.M. Inhibition of lipid peroxidation and detoxification of lipid peroxides with protective enzyme systems (superoxide dismutase, glutathione peroxidase and glutathione reductase) in experimental malignant growth. Reports of Academy of Sciences of USSR 1976; 226(3): 705–708.
Lopez-Otin C., Blasco M.A., Partridge L. et al. The hallmarks of aging. Cell 2013; 153(6): 1194–1217. CrossRef PubMed
Ohkawa H., Ohahi N., Jadi R. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95(2): 351–358. CrossRef
Pogozhykh D., Prokopyuk V., Pogozhykh O. et al. Influence of factors of cryopreservation and hypothermic storage on survival and functional parameters of multipotent stromal cells of placental origin. PLoS One 2015; 10(10): 1–25. CrossRef PubMed
Prokopyuk V.Yu., Prokopyuk O.S., Musatova I.B. et al. Safety of placental, umbilical cord and fetal membrane explants after cryopreservation. Cell and Organ Transplantology 2015; 3(1): 34–38. CrossRef
Ravin H.A. Rapid test for hepatolenticular degeneration. Lancet 1956; 1: 7267–7271. CrossRef
Schevchenko N.O., Somova K.V., Prokopyuk V.Yu. et al. Dyna-mics of activity and duration of functioning of cryopreserved cryoextract, placental cells and fragments in the organism of experimental animals. Morphologia 2016; 10(2): 93–98.
Silini A.R., Cargnoni A., Magatti M. et al. The long path of human placenta, and its derivatives, in regenerative medicine. Front Bioeng Biotechnol 2015; 19(3): 162. CrossRef
Stefanov O.V., editor. Preclinical trials of medicines [guidelines]. Kyiv: Avitsena; 2001.
Xie C., Jin J., Lv X. et al. Antiaging effect of transplanted amniotic membrane mesenchymal stem cells in a premature aging model of Bmi-1 deficiency. Sci Rep 2015; 5: 13975. CrossRef PubMed
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