Lyophilised human cord blood leukoconcentrate triggers formation of dendritic cells with a tolerogenic phenotype
Ключевые слова:
lyophilized human cord blood leukoconcentrate, dendritic cells, tolerogenic phenotypeАннотация
Probl Cryobiol Cryomed. 2026; 36(1): 51—57
Библиографические ссылки
Akel S, Regan D, Wall D, et al. Current thawing and infusion practice of cryopreserved cord blood: the impact on graft quality, recipient safety, and transplantation outcomes. Transfusion. 2014; 54(11): 2997-3009. CrossRef
Bros M, Haas K, Moll L, Grabbe S. RhoA as a key regulator of innate and adaptive immunity. Cells Cells [Internet]. 2019 Jul 17 [cited 2025 Jul 18]; 8(7): 733. Available from: https://www.mdpi.com/2073-4409/8/7/733 CrossRef
Dauven D, Ehrentraut S, Langwisch S, et al. Immune modulatory effects of human chorionic gonadotropin on dendritic cells supporting fetal survival in murine pregnancy. Front Endocrinol (Lausanne) [Internet]. 2016 Nov 15 [cited 2025 Jul 28]; 7: 146. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC5108759 CrossRef
Dixon KO, van der Kooij SW, Vignali DA, van Kooten C. Human tolerogenic dendritic cells produce IL-35 in the absence of other IL-12 family members. Eur J Immunol. 2015; 45(6): 1736-47. CrossRef
Drohan L, Harding JJ, Holm B, et al. Selective developmental defects of cord blood antigen-presenting cell subsets. Hum Immunol. 2004; 65(11): 1356-69. CrossRef
Foundation for the Accreditation of Cellular Therapy (FACT), International Netcord Fundation. NetCord-FACT International Standards for Cord Blood Collection, Banking, and Release for Administration Summary of Changes, 5.2.010, 6th Edition Cord Blood Standards Summary of Changes, [Internet]. 2016 Jul 01 [cited 2025 Jul 28]. Available from: https://www.tga.gov.au/sites/default/files/consultation-revision-tgo75-haematopoietic-progenitor-cells-derived-from-cord-blood-attach-3.pdf
Goldmann O, Nwofor OV, Chen Q, Medina E. Mechanisms underlying immunosuppression by regulatory cells. Front Immunol[Internet]. 2024 Feb 6 [ciited 2025 Feb 15]; 15: 1328193. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC10876998 CrossRef
Goltsev A, Dubrava T, Yampolska K, et al. The substantiation of adoptive transfer of tolerogenic dendritic cells for treatment of rheumatoid arthritis in mice. Cell Organ Transplant. 2019; 7(2): 125-31. CrossRef
Goltsev AM, Lutsenko OD, Ostankova LV. Cryobiological technologies in providing tolerogenic potential of cryoconserved and lyophilized cord blood leukoncentrate. CryoLetters. 2021: 42(6): 373-4.
Goltsev AM, Taranik GC, Grisha IG, et al, inventors; Institute for Problems of Cryobiology and Cryomedisine, assignee. [Method of Lyophilization of leukoconcentrate of cord blood]. Ukrainian patent 113006, 2017. Jan 10. Ukrainian.
Goltsev AN, Dubrava TG, Yampolskaya EE, et al. [The optimization method of isolation of immature dendritic cells]. Fiziol. Zh. 2018; 64(6): 32-9. Ukrainian.
Haddock R, Lin-Gibson S, Lumelsky N, et al. Manufacturing cell therapies: the paradigm shift in health care of this century. NAM Perspectives. Discussion Paper. National Academy of Medicine, Washington, DC [Internet]. 2017 June 23 [cited 2025 Sept 09]. Available from: https://nam.edu/wp-content/uploads/2017/06/Manufacturing-Cell-Therapies.pdf
Khare P, Bose A, Singh P, et al. Gonadotropin and tumorigenesis: direct and indirect effects on inflammatory and immunosuppressive mediators and invasion. Mol Carcinog. 2017; 56(2): 359-70. CrossRef
Koval GK, Lutsenko OD, Grisha IG, et al. Impact of lyophilisation on integrity of structural and functional characteristics of human cord blood leukoncentrate. Probl Cryobiol Cryomed. 2019; 29(4), 332-43. CrossRef
Koval H, Lutsenko O, Bondarovych M, et al. Therapy with cryopreserved and lyophilized cord blood leukoconcentrates in experimental atopic dermatitis. Probl Cryobiol Cryomed. 2024; 34(4), 282-6. CrossRef
Kryczanowsky F, Raker V, Graulich E, et al. IL-10-modulated human dendritic cells for clinical use: Identification of a stable and migratory subset with improved tolerogenic activity. J Immunol. 2016; 197(9): 3607-17. CrossRef
Kysielova H, Yampolska K, Dubrava T, et al. Improvement of bone marrow mononuclear cells cryopreservation methods to increase the efficiency of dendritic cell production. Cryobiology. 2022; 106: 122-30. CrossRef
Lee M, Jeong SY, Ha J, Kim J-S, et al. Low immunogenicity of allogeneic human umbilical cord blood-derived mesenchymal stem cells in vitro and in vivo. Biochem Biophys Res Commun. 2014; 446(4): 983-9. CrossRef
Liu J, Cao X. Regulatory dendritic cells in autoimmunity: A comprehensive review. J Autoimmun. 2015; 63: 1-12. CrossRef
Liu Q, Lv Y, Zhao M, et al. PD-L1 blockade improves immune dysfunction of spleen dendritic cells and T-cells in zymosan-induced multiple organs dysfunction syndromes. Int J Clin Exp Pathol. 2015; 8(2): 1374-83. PubMed
Mackern-Oberti JP, Jara EL, Riedel CA, Kalergis AM. Hormonal modulation of dendritic cells differentiation, maturation and function: implications for the initiation and progress of systemic autoimmunity. Arch Immunol Ther Exp (Warsz). 2017; 65(2): 123-36. CrossRef
Morali K, Giacomello G, Vuono M, Gregori, S. Leveraging current insights on IL-10-producing dendritic cells for developing effective immunotherapeutic approaches. FEBS Lett. 2025; 599: 2025-47. CrossRef
Moreau A, Varey E, Bouchet-Delbos L, et al. Cell therapy using tolerogenic dendritic cells in transplantation. Transplant Res. [Internet]. 2012 Sep 28 [cited 2025 Jul 2]; 1(1): 13. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC3560975 CrossRef
Natan D, Nagler A, Arav A. Freeze-drying of mononuclear cells derived from umbilical cord blood followed by colony formation. PLoS One. [Internet]. 2009 [cited 2025 Jun 14]; 4(4): e5240. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC2667668 CrossRef
Navarro-Barriuso J, Mansilla MJ, Quirant-Sánchez B, et al. Vitamin D3-Induced Tolerogenic Dendritic Cells Modulate the Transcriptomic Profile of T CD4+ Cells Towards a Functional Hyporesponsiveness. Front Immunol. [Internet]. 2021 Jan 20 [cited 2025 Jul 10]; 11: 599623. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC7856150 CrossRef
Ocaña-Morgner C, Götz A, Wahren C, et al. SWAP-70 restricts spontaneous maturation of dendritic cells. J Immunol. 2013; 190(11): 5545-58. CrossRef
Ochando J, Ordikhani F, Jordan S, et al. Tolerogenic dendritic cells in organ transplantation. Transpl Int. 2020; 33(2): 113-27. CrossRef
Podgrabinska S, Skobe M. Role of lymphatic vasculature in regional and distant metastases. Microvasc Res. 2014; 95: 46-52. CrossRef
Raker VK, Domogalla MP, Steinbrink K. Tolerogenic dendritic cells for regulatory T cell induction in man. Front Immunol. [Internet]. 2015 Nov 9 [cited 2025 Jan 15]; 6: 569. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC4638142 CrossRef
Reeder C, Sylvester-Armstrong K, Becker MW, et al. The effect of pregnant serum, cord blood serum and hCG on jurkat T-cell IL2 secretion. American Journal of Obstetrics & Gynecology. [Internet]. 2023 Jan 1 [cited 2025 Jan 16]; 228(1): S 445. Available from: https://www.ajog.org/article/S0002-9378(22)01654-4/fulltext CrossRef
Sarvaria A, Basar R, Mehta RS, et al. IL-10+ regulatory B cells are enriched in cord blood and may protect against cGVHD after cord blood transplantation. Blood. 2016; 128(10): 1346-61. CrossRef
Schittenhelm L, Hilkens CM, Morrison VL. β2 Integrins as regulators of dendritic cell, monocyte, and macrophage function. Front Immunol. [Internet]. 2017 Dec 20 [cited 2025 Sept 20]; 8: 1866. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC5742326 CrossRef
Segerer SE, Müller N, van den Brandt J, et al. Impact of female sex hormones on the maturation and function of human dendritic cells. Am J Reprod Immunol. 2009; 62(3): 165-73. CrossRef
Steinbrink K, Wölfl M, Jonuleit H, et al. Induction of tolerance by IL-10-treated dendritic cells. J Immunol. 1997; 159(10): 4772-80. CrossRef
Švajger U, Rožman P. Induction of tolerogenic dendritic cells by endogenous biomolecules: an update. Front Immunol. [Internet]. 2018 Oct 26 [cited 2025 Sept 25]; 9: 2482. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC6212600 CrossRef
Wan H, Versnel MA, Leijten LM, et al. Chorionic gonadotropin induces dendritic cells to express a tolerogenic phenotype. J Leukoc Biol. 2008; 83(4): 894-901. CrossRef
Wculek SK,Cueto FJ, Mujal AM, et al. Dendritic cells in cancer immunology and immunotherapy. Nat Rev Immunol. 2020; 20(1): 7-24. CrossRef
Yang J, Yang Y, Ren Y, et al. A mouse model of adoptive immunotherapeutic targeting of autoimmune arthritis using allo-tolerogenic dendritic cells. PLoS One. [Internet]. 2013 Oct 24 [cited 2025 Jul 5]; 8(10): e77729. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC3812020 CrossRef
Yoo S, Ha SJ. Generation of Tolerogenic Dendritic Cells and Their Therapeutic Applications. Immune Netw. 2016; 16(1): 52-60. CrossRef
Загрузки
Опубликован
Как цитировать
Выпуск
Раздел
Лицензия
Это произведение доступно по лицензии Creative Commons «Attribution» («Атрибуция») 4.0 Всемирная.
Авторы, публикующие в данном журнале, соглашаются со следующим:
- Авторы сохраняют за собой авторские права на работу и предоставляют журналу право первой публикации работы на условиях лицензии Creative Commons Attribution License, которая позволяет другим распространять данную работу с обязательным сохранением ссылок на авторов оригинальной работы и оригинальную публикацию в этом журнале.
- Авторы сохраняют право заключать отдельные контрактные договоренности, касающиеся не-эксклюзивного распространения версии работы в опубликованном здесь виде (например, размещение ее в институтском хранилище, публикацию в книге), со ссылкой на ее оригинальную публикацию в этом журнале.
- Авторы имеют право размещать их работу в сети Интернет (например в институтском хранилище или персональном сайте) до и во время процесса рассмотрения ее данным журналом, так как это может привести к продуктивному обсуждению и большему количеству ссылок на данную работу (См. The Effect of Open Access).
